Publications by authors named "Ashley L Azadeh"
Article Synopsis
- The synthesis of proline involves an unstable intermediate called γ-L-glutamyl 5-phosphate (GP), which was thought to be protected from turning into a useless product through protein interactions.
- For almost 70 years, it was believed that a direct connection between two enzymes (glutamate 5-kinase and GP reductase) helped channel GP and prevent its instability.
- However, new evidence shows that these interactions aren't necessary for proline synthesis, as GP can diffuse quickly enough to reach GP reductase before it has a chance to cyclize and become inactive.
Tailocins are bactericidal protein complexes produced by a wide variety of bacteria that kill closely related strains and may play a role in microbial community structure. Thanks to their high specificity, tailocins have been proposed as precision antibacterial agents for therapeutic applications. Compared to tailed phages, with whom they share an evolutionary and morphological relationship, bacterially produced tailocins kill their host upon production but producing strains display resistance to self-intoxication.
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