Publications by authors named "Ashley J B Maclean"
Article Synopsis
- Tramadol is a synthetic opioid that also affects serotonin and norepinephrine levels, used to manage acute pain.
- Fibromyalgia is a chronic pain condition lacking FDA-approved treatments, with duloxetine, milnacipran, and pregabalin being the only effective medications.
- The paper reviews tramadol's effectiveness for fibromyalgia, finding reasonable evidence to support its use as a second-line option for tougher cases.
Background: Memory blockade is an essential component of the anesthetic state. However, postanesthesia memory deficits represent an undesirable and poorly understood adverse effect. Inhibitory α5 subunit-containing γ-aminobutyric acid subtype A receptors (α5GABAA) are known to play a critical role in memory processes and are highly sensitive to positive modulation by anesthetics.
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