"Minimally symptomatic" congenital cytomegalovirus infection: latest data and emerging concepts.

Purpose Of Review: Universal and targeted screening of newborns for congenital cytomegalovirus (CMV) infection is increasing globally. Questions remain concerning the management of infants who have been identified with congenital CMV infection, especially those with "minimally symptomatic" or clinically inapparent infection. Our objective is to discuss current management of CMV-infected neonates with a focus on less affected infants with or without sensorineural hearing loss (SNHL).

Violence and Disposability at the Intersection of Twin Pandemics.

COVID-19 and anti-Black violence represent interlocking pandemics animated by necropolitics, the power to determine who lives and who dies. By expanding our understanding of violence to include its structural and cultural forms alongside direct bodily harm, we must also expand our commitment to end violence. Labor educators, organizers, and workers are uniquely positioned to articulate this more expansive definition and advocate for the eradication of violence in all its forms.

Ex vivo isolation, expansion and bioengineering of CCR7+CD95-/or CD62L+CD45RA+ tumor infiltrating lymphocytes from acute myeloid leukemia patients' bone marrow.

T cell based immunotherapies can be applicable to acute myeloid leukemia (AML). Therefore, the selection of optimal T cells, cell manufacturing, and therapeutic T cell engineering are essential for the development of effective adoptive T cell therapies for AML. Autologous tumor-infiltrating lymphocytes (TILs) have been in clinical trials to treat solid malignancies.

Implementation Experience With Meningococcal Serogroup B Vaccines in the United States: Impact of a Nonroutine Recommendation.

Background: Meningococcal serogroup B (MenB) is the leading cause of invasive meningococcal disease among US adolescents and young adults, accounting for 62% of cases in 16-23-year-olds in 2018. Since 2015, the Advisory Committee on Immunization Practices (ACIP) has recommended vaccination of healthy adolescents against MenB based on shared clinical decision-making (previously called "Category B" or individual clinical decision-making). However, MenB vaccine coverage and series completion rates remain low.

Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth.

Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.

Study Design: We conducted a multicenter, retrospective, and prospective study of pediatric patients hospitalized with acute SARS-CoV-2 infections and multisystem inflammatory syndrome in children (MIS-C) at 8 sites in New York, New Jersey, and Connecticut.

Results: We identified 281 hospitalized patients with SARS-CoV-2 infections and divided them into 3 groups based on clinical features.

Hybrid dysgenesis in results in clusters of mitotic recombination and loss-of-heterozygosity but leaves meiotic recombination unaltered.

Background: Transposable elements (TEs) are endogenous mutagens and their harmful effects are especially evident in syndromes of hybrid dysgenesis. In , hybrid dysgenesis is a syndrome of incomplete gonadal atrophy that occurs when males with multiple active TE families fertilize females that lack active copies of the same families. This has been demonstrated to cause the transposition of paternally inherited TE families, with gonadal atrophy driven by the death of germline stem cells.

Pediatric Myocarditis Protocol: An Algorithm for Early Identification and Management with Retrospective Analysis for Validation.

Myocarditis is an inflammatory disease of the myocardium with numerous different etiologies, the vast majority of which are infectious in origin. Patients afflicted with myocarditis can have variable presentations from flu-like symptoms to cardiogenic shock and sudden death, thus making the diagnosis difficult. The purpose of this study is the development of an algorithm for early identification and management of myocarditis based on a review of the published data and available literature.

The Interpersonal Transaction Scales-8 (ITS-8): A Circumplex-Based, Behaviorally Anchored Instrument Based on the CLOIT-R.

Using the Checklist of Interpersonal Transactions-Revised (CLOIT-R; Kiesler, 2004) as a basis, a new behaviorally anchored instrument was developed with a graded-response scale, simplified item wording, substantially fewer items, and improved consistency with the interpersonal circumplex. In a community sample (Study 1), the graded response format with simplified items showed improved octant-scale reliabilities, as well as circular structure and convergent validity comparable to the CLOIT-R. Items that performed consistently across community and undergraduate samples (Study 2) were then selected to produce an inventory with half as many items as the CLOIT-R, but with good octant-scale reliabilities and excellent circular structure.

Pre-partying Amongst Students in the UK: Measuring Motivations and Consumption Levels Across Different Educational Contexts.

We sought to explore the motivations for pre-partying amongst UK student drinkers who reported pre-partying at least once per month. Two distinct educational settings were included: colleges, where the majority of students are below the legal age for drinking, and university, where all students would be legally allowed to drink. A cross-sectional correlational design was adopted.

Influenza-Associated Acute Necrotizing Encephalopathy in Siblings.

Encephalopathy is an important complication associated with influenza, most frequently observed in young children, with a wide range of severity. The most severe category of influenza-associated encephalopathy (IAE) is acute necrotizing encephalopathy (ANE), characterized by high frequency of neurologic sequelae and fatal outcomes. We report two young siblings who developed fever and seizures with altered mental status.

Two Infants with Presumed Congenital Zika Syndrome, Brownsville, Texas, USA, 2016-2017.

Since 2007, Zika virus has spread through the Pacific Islands and the Americas. Beginning in 2016, women in Brownsville, Texas, USA, were identified as possibly being exposed to Zika virus during pregnancy. We identified 18 pregnant women during 2016-2017 who had supportive serologic or molecular test results indicating Zika virus or flavivirus infection.

Murine Typhus in South Texas Children: An 18-year Review.

Background: Murine typhus is a zoonotic infection caused by Rickettsia typhi that remains endemic in South Texas. In 2003, only 9 Texas counties reported murine typhus compared with 41 counties in 2013.

Methods: A retrospective study of children discharged with a confirmed diagnosis of murine typhus from Driscoll Children's Hospital between January 1998 and September 2016.

Clinical application of voriconazole concentrations in the treatment of invasive aspergillosis.

Objective: To review the current literature to determine the clinical application of therapeutic drug monitoring of voriconazole in the treatment of invasive aspergillosis (IA).

Data Source: A MEDLINE search (1966-June 2008) was performed using the search terms voriconazole, aspergillosis, levels, monitoring, and serum concentration.

Study Selection And Data Extraction: All pertinent English-language literature on voriconazole use in adults was included for evaluation.