DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis.

Context: A genetic etiology accounts for the majority of unexplained primary ovarian insufficiency (POI).

Objective: We hypothesized a genetic cause of POI for a sister pair with primary amenorrhea.

Design: The study was an observational study.

Metyrapone for Long-Term Medical Management of Cushing's Syndrome.

Cushing's syndrome is characterized by any cause of excess cortisol in the blood and produces many physiologic consequences. Left untreated, Cushing's is associated with significant morbidity and mortality. Seventy percent of endogenous cases of Cushing's syndrome are secondary to a pituitary tumor; because of this, the primary mode of management is surgical resection of the tumor.