Objective: To report successful surgical repair of a grade IV lateral patellar luxation in a 437-kg heifer.
Study Design: Case report.
Animal: Seventeen-month-old Holstein heifer (437 kg).
Cortical development requires the precise timing of neural precursor cell (NPC) terminal mitosis. Although cell cycle proteins regulate terminal mitosis, the factors that influence the cell cycle machinery are incompletely understood. Here we show in mice that myeloid cell leukemia 1 (Mcl1), an anti-apoptotic Bcl-2 protein required for the survival of NPCs, also regulates their terminal differentiation through the cell cycle regulator p27(Kip1).
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