Expression of avian Groucho-related genes (Grgs) during embryonic development.

Groucho-related genes (Grgs) encode transcriptional co-repressors of Lef/Tcf and Hes proteins, which are mediators of Wnt and Notch signalling, respectively. Thus, they are important players in the developmental processes controlled by Wnt and Notch signalling, including lateral inhibition, segmentation and dorso-ventral patterning. We have cloned the avian homologues of Grg genes and examined their expression pattern by whole-mount in situ hybridisation between Hamburger-Hamilton (HH) stages 3 and 24.