Publications by authors named "Ashley Beccles"
Research Question: Does using an objective time-lapse imaging algorithm (TLIA) after IVF relate to conventional morphological assessment of human blastocysts as a prognosticator for live birth?
Design: Prospective use of a TLIA to select embryos in multicentre IVF clinics all using the same strictly controlled laboratory protocols. Each blastocyst was given a ranking from A to D, with the highest rank preferred for fresh transfer. This ranking was retrospectively compared with a given morphological score, which was blinded to the TLIA rank; all embryos were cultured under the same conditions.
Article Synopsis
- The research investigates if embryos, specifically blastocysts, can be ranked using morphokinetic-based algorithms to predict the likelihood of live births.
- A study analyzed 781 single blastocyst transfers and found that higher-ranked embryos (A) have significantly better odds of resulting in live births compared to lower ranks (B, C, D), with a clear drop in success from rank A (52.5%) to rank D (13.2%).
- The findings suggest that using time-lapse imaging to assess blastocysts may be more effective for predicting live births than traditional methods based on embryo morphology alone.
The increasing corpus of clinical studies using time-lapse imaging for embryo selection demonstrates considerable variation in study protocols and only limited-sized study cohorts. Outcome measures are based on implantation or clinical pregnancy; some predict blastulation from early cleavage-stage data, and few have evaluated live birth. Erroneously, most studies treat the embryos as independent variables and do not include patient or treatment variables in the statistical analyses.
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- The study focuses on the impact of the ANXA5 M2 haplotype, a potential procoagulant biomarker, on pregnancy outcomes in couples undergoing IVF and evaluates the effectiveness of testing and treating with low molecular weight heparin (LMWH).
- Involving 103 IVF couples with the ANXA5 M2 haplotype, the study compares their live birth rates to 1000 unscreened couples, finding that ANXA5 M2 carriers had similar live birth rates to both the fertile comparison group and matched controls.
- Results showed that treated male carrier couples had a higher live birth incidence compared to female carrier couples, suggesting that the management protocol for treating ANXA5 M2 positive