Efficacy of Escherichia coli O157:H7 siderophore receptor/porin proteins-based vaccine in feedlot cattle naturally shedding E. coli O157.

Escherichia coli O157 is a foodborne pathogen commonly isolated from beef cattle feces and can enter the food chain at harvest. A relatively new vaccine technology uses the iron requirement of pathogenic bacteria by targeting the siderophore receptor and porin proteins (SRP). We evaluated the efficacy of an anti-E.

Use of a siderophore receptor and porin proteins-based vaccine to control the burden of Escherichia coli O157:H7 in feedlot cattle.

Objective: To quantify the efficacy of a siderophore receptor and porin (SRP) proteins-based vaccine on the burden of Escherichia coli O157:H7 in feedlot cattle.

Methods: Two research trials were conducted in field conditions. In each trial, cattle (n = 1252 in trial #1; n = 1284 in trial #2) were systematically divided into 20 pens and were administered either the E.