Publications by authors named "Ashley Alarcon Rozas"
Purpose: To develop recommendations involving targeted therapies for patients with advanced gastroesophageal cancer.
Methods: The American Society of Clinical Oncology convened an Expert Panel to conduct a systematic review of relevant studies and develop recommendations for clinical practice.
Results: Eighteen randomized controlled trials met the inclusion criteria for the systematic review.
Purpose: To provide expert guidance to clinicians and policymakers in resource-constrained settings on the management of patients with late-stage colorectal cancer.
Methods: ASCO convened a multidisciplinary, multinational Expert Panel that reviewed existing guidelines, conducted a modified ADAPTE process, and used a formal consensus process with additional experts for two rounds of formal ratings.
Results: Existing sets of guidelines from four guideline developers were identified and reviewed; adapted recommendations from five guidelines form the evidence base and provided evidence to inform the formal consensus process, which resulted in agreement of ≥ 75% on all recommendations.
Article Synopsis
- Chemotherapy is the standard treatment for locally advanced HER2-positive breast cancer, but using targeted therapies like afatinib may offer more benefits compared to traditional options like trastuzumab and lapatinib.
- In a study of treatment-naive patients, those receiving afatinib showed a comparable response rate to trastuzumab and lapatinib, but with a higher incidence of drug-related side effects.
- Overall, afatinib showed promising clinical activity with a safety profile typical of other similar targeted therapies, indicating it could be a viable alternative in neoadjuvant therapy for this type of breast cancer.