Publications by authors named "Ashlesha Gogate"
Article Synopsis
- - The study focused on understanding the genetic causes of autism spectrum disorder (ASD) by sequencing the DNA of 754 individuals from 195 families, identifying a total of 38,834 new genetic variants.
- - Researchers discovered 92 potentially harmful genetic variations in 73 known genes among 68 individuals with ASD, along with 158 likely damaging variants in 120 other candidate genes.
- - The findings enhance our knowledge of ASD genetics, revealing patterns linked to brain development and cellular signaling, which could aid in diagnosing and developing treatments for the disorder.
Chromatin regulation plays a pivotal role in establishing and maintaining cellular identity and is one of the top pathways disrupted in autism spectrum disorder (ASD). The hippocampus, composed of distinct cell types, is often affected in patients with ASD. However, the specific hippocampal cell types and their transcriptional programs that are dysregulated in ASD are unknown.
View Article and Find Full Text PDFAutism spectrum disorder (ASD) is a group of complex neurodevelopmental conditions affecting communication and social interaction in 2.3% of children. Studies that demonstrated its complex genetic architecture have been mainly performed in populations of European ancestry.
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