Publications by authors named "Ashlee N Lamason"
Article Synopsis
- Mitochondrial DNA (mtDNA) variants can lead to various diseases, and a specific variant allele frequency (VAF) level must be reached to trigger biochemical defects, known as the biochemical threshold.
- The study reviewed 76 publications on how VAF impacts oxidative phosphorylation (OXPHOS) activities across different human tissues, revealing inconsistencies and suggesting the threshold could be less than the commonly cited >60% VAF.
- Analysis revealed that while some cases with similar VAF levels showed varying biochemical activity, more research is needed to clarify the biochemical thresholds for specific mtDNA variants in related cell types.
