Publications by authors named "Ashlea Scruton"
Article Synopsis
- The study investigates the prevalence of Enlarged Perivascular Spaces (ePVS), linked to Cerebral Small Vessel Disease (CSVD), across different ages and sexes in a large community sample.
- Findings show that ePVS prevalence rises with age for both men and women, correlating with an increased presence of vascular risk factors like hypertension and smoking.
- The results suggest that ePVS could serve as a useful biomarker for age-related brain vascular issues, indicating a connection between vascular health and cognitive decline.
Objective: Enlarged perivascular spaces have emerged as markers of cerebral small vessel disease and are linked to perivascular drainage dysfunction. The apolipoprotein E-ɛ4 (APOE-ɛ4) allele is the strongest genetic risk factor for cerebral amyloid angiopathy and Alzheimer's neuropathology, but the underlying mechanisms remain unclear. We studied the relationship between APOE-ɛ4 and the topography and burden of enlarged perivascular spaces to elucidate underlying mechanisms between APOE-ɛ4 and adverse clinical outcomes.
View Article and Find Full Text PDF