Explainable artificial intelligence to predict the risk of side-specific extraprostatic extension in pre-prostatectomy patients.

Introduction: We aimed to develop an explainable machine learning (ML) model to predict side-specific extraprostatic extension (ssEPE) to identify patients who can safely undergo nerve-sparing radical prostatectomy using preoperative clinicopathological variables.

Methods: A retrospective sample of clinicopathological data from 900 prostatic lobes at our institution was used as the training cohort. Primary outcome was the presence of ssEPE.

Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium.

The mammalian kidney undergoes cell interactions between the epithelium and mesenchyme to form the essential filtration unit of the kidney, termed the nephron. A third cell type, the kidney stroma, is a population of fibroblasts located in the kidney capsule, cortex and medulla and is ideally located to affect kidney formation. We found β-catenin, a transcriptional co-activator, is strongly expressed in distinctive intracellular patterns in the capsular, cortical, and medullary renal stroma.

Insights into the renal pathogenesis in Schimke immuno-osseous dysplasia: A renal histological characterization and expression analysis.

Schimke immuno-osseous dysplasia (SIOD) is a pleiotropic disorder caused by mutations in the SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like-1 (SMARCAL1) gene, with multiple clinical features, notably end-stage renal disease. Here we characterize the renal pathology in SIOD patients. Our analysis of SIOD patient renal biopsies demonstrates the tip and collapsing variants of focal segmental glomerulosclerosis (FSGS).

A case of cardiac tamponade with a "small" pericardial effusion and superior vena cava syndrome.

In this article, we report a case of a previously healthy 11-year-old male who presented to our university hospital with a mediastinal mass, a left and right pleural effusion, and a small pericardial effusion of 5 mm, detected on computed tomography scan and echocardiography. On assessment, he had all the clinical features of superior vena cava syndrome and tamponade, including muffled heart sounds, tachycardia, and pulsus paradoxus. The patient developed increasing respiratory distress requiring tracheal intubation and mechanical ventilation, and despite drainage of his larger pleural effusion, continued to experience symptoms of respiratory distress.

Suture repair versus arrow repair for symptomatic meniscus tears of the knee: a systematic review.

A healthy meniscus is important for normal function of the knee. Numerous studies support that the repair of a torn meniscus is important to prevent degenerative changes in the knee. The ability to repair torn menisci is based on several factors including location, tear orientation, chronicity, and concomitant ligamentous knee injuries.