Coronary artery disease and percutaneous coronary intervention in patients with severe chronic kidney disease.

Coronary artery disease (CAD) is the leading cause of mortality among patients with chronic kidney disease (CKD), presenting unique challenges in diagnosis and management. Advanced CKD patients often present with atypical symptoms, and conventional diagnostic and interventional approaches carry risks, including contrast-induced nephropathy and the potential need for renal replacement therapy. These risks have led to the phenomenon of "renalism," where necessary procedures may be deferred due to concerns over renal injury.

Bioremediation of catecholic pollutants with novel oxygen-insensitive catechol 2,3-dioxygenase and its potential in biomonitoring of catechol in wastewater.

The oxygenases are essential in the bioremediation of xenobiotic pollutants. To overcome cultivability constraints, this study aims to identify new potential extradiol dioxygenases using the functional metagenomics approach. RW1-4CC, a novel catechol 2,3-dioxygenase, was isolated using functional metagenomics approach, expressed in a heterologous system, and characterized thoroughly using state-of-the-art techniques.

Incremental Role of Cardiac CT Angiography in the Assessment of Left Ventricular Diastolic Function in Patients With Suspected Coronary Artery Disease With Normal Ejection Fraction: A Comparison With Transthoracic Echocardiography.

Objective: Diastolic dysfunction (DD) is defined as impaired left ventricular (LV) relaxation, caused by structural or functional heart diseases. We sought to assess the role of cardiac CT angiography (CCTA) as a tool to evaluate LV DD in patients with normal EF using the diastolic expansion index (DEI), as compared to transthoracic echocardiography (TTE) as the gold standard.

Methods: Patients presenting with atypical chest pain with suspected coronary artery disease (CAD) and having a normal LV ejection fraction on TTE underwent CCTA using a dual source CT scanner.

Short-term and long-term fluoride stress induce differential molecular and transcriptional regulation and variable ranges of fluoride tolerance in two indica rice () varieties.

The aim of this study was to decipher the reprogramming of protective machineries and sulfur metabolism, as responses to time-dependent effect of fluoride stress for 10 and 20days in two indica rice (Oryza sativa ) varieties. Unregulated accumulation of fluoride via chloride channels (CLC1 and CLC2) in 10-day-old (cv. Khitish) and 20-day-old (cv.

Assessment of industrial effluent discharges contributing to Ganga water pollution through a multivariate statistical framework: investigating the context of Indian industries.

The swift industrial expansion has posed significant environmental challenges, particularly in the context of water pollution. Industrial effluents consist of substantial amounts of harmful pollutants that enter the main rivers via various tapped and untapped drains/local water streams, causing alterations in their physical and chemical properties. This study investigated 153 grossly polluting industries (GPIs) that were identified to release their effluents into the main rivers through different drains within multiple sectors in the industrial zone of four northern states of India in 2023.

Impact of the Good Samaritan Law on bystander intervention willingness and perceived legal risks in India.

Background: Road traffic crashes (RTCs) are a global health burden, particularly in India, where response times for first responders can be prolonged. Prior to enactment of a Good Samaritan Law (GSL) in 2016, involved bystanders could face criminal and financial liability for assisting at an RTC site. This study evaluates the impact of GSL on bystander RTC attitudes, awareness, and experiences in India, comparing outcomes pre- and post-GSL implementation across metropolitan cities (MCs) and nonmetropolitan cities (NMCs).

Stimulant Management of Attention-Deficit/Hyperactivity Disorder for the Pediatric Prescriber: A Review of Stimulant-Dosing Strategies and An Overview of New Stimulants.

Pediatricians are often the first providers to assess and treat attention-deficit/hyper-activity disorder (ADHD) in youth. While a variety of pharmacological and psychosocial interventions exist for ADHD, stimulants remain the first-line medication treatment. Many stimulant formulations now exist, providing the pediatric prescriber with a diverse repertoire of treatment options.

Lattice thermal conductivity and phonon properties of polycrystalline graphene.

Using the spectral energy density method, we predict the phonon scattering mean lifetimes of polycrystalline graphene (PC-G) having polycrystallinity only along the -axis with seven different misorientation (tilt) angles at room temperature. Contrary to other studies on PC-G samples, our results indicate a strong dependence of the thermal conductivity (TC) on the tilt angles which we attribute to careful preparation of our grain boundaries-based samples without introducing any local strains and ensuring periodic boundary conditions for the supercells along the and axes. We also show that the square of the group velocity components along and axes and the phonon lifetimes are uncorrelated and the phonon density of states are almost the same for all samples with different tilt angles.

Corrigendum to "Identifying treatment non-responders based on pre-treatment gait characteristics - A machine learning approach." [Volume , Issue 11, November 2023, e21242].

[This corrects the article DOI: 10.1016/j.heliyon.

"Right Lower Lobe Lung Pathology": A Potential Mimic of Pneumoperitoneum.

Kumar R, Singh AK. "Right Lower Lobe Lung Pathology": A Potential Mimic of Pneumoperitoneum. Indian J Crit Care Med 2024;28(12):1182-1183.

Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: Predictors of Early and Late Complications.

Background Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is often considered the preferred surgical treatment for ulcerative colitis. This study was conducted to investigate the early and late complications of ileal pouch-anal anastomosis in patients with ulcerative colitis, as well as the factors associated with these complications. Methodology All relevant clinical and operative data of patients (n = 101) who underwent IPAA for ulcerative colitis between January 1995 and December 2018 were retrieved from a prospectively maintained database.

Meditation as a Therapy or a Threat: A Case Series.

Meditation is an approach to self-regulate the emotions. Meditation has a beneficial effect on both physical and mental health. Various forms of meditation practices prevail in many religions and cultures for human well-being.

Association Between Chronic Kidney Disease Risk Categories and Abdominal Aortic Calcification: Insights From the National Health and Nutrition Examination Survey.

Background: Abdominal aortic calcification (AAC) is a critical indicator of cardiovascular risk, particularly in patients with chronic kidney disease (CKD). Traditional classification systems may underestimate the risk in those with moderate CKD. This study aimed to evaluate the association between CKD risk categories - defined by both estimated glomerular filtration rate (eGFR) and albuminuria - and the prevalence of severe AAC.

A Retrospective Chart Analysis Comparing Breast Cancer Detection Rates Between Annual Versus Biennial Mammograms.

Background: Per American Cancer Society, breast cancer is one of the most prevalent causes of cancer-related mortality in women in the United States. Different organizations vary in their recommendations regarding frequency of mammograms, with the United State Preventive Service Taskforce recommending biennial screening and other organizations like American College of Radiology promoting annual screening. The purpose of this study was to analyze institutional data to compare breast cancer detection rates among women undergoing annual vs.

Preliminary evaluation of FAPI-04-PET/CT for differentiating recurrence and post-treatment changes in high-grade gliomas.

Fibroblast-activated protein (FAP) expression in glial cells is attributed to FAP-positive foci on tumor vessels and neoplastic cells. Preclinical and pilot studies have shown FAP expression in high-grade gliomas. We aimed at comparing PET imaging with FAP-inhibitor (FAPI-PET) with current standard, i.

Identification of CD8+ Immunogenic Peptides for Vaccine Design against Nipah Virus in Humans.

Background: Nipah virus is a pathogenic virus of ruinous zoonotic potential with inflated rate of mortality in humans.

Methods: Considering the emerging threat of this pandemic virus, the present investigation amid to design vaccine by using the bioinformatics tools such as host and virus codon usage analysis, CD8+ peptide prediction, immunogenicity/allergenicity/toxicity, MHC-I allele binding prediction and subsequent population coverage and MHC-I-peptide docking analysis.

Results: In this study (conducted in 2022 at School of Biotechnology, Katra, India), a set of 11 peptides of the structural proteins of Nipah Virus were predicted and recognized by the set of MHC-I alleles that are expressed in 92% of the global human population.

Analgesic efficacy of ultrasound-guided retrolaminar block in truncal surgeries: A narrative review.

Postoperative pain management in patients undergoing thoracoabdominal surgery always remains challenging for the anesthesiologist. As a method of pain management, multimodal analgesia is commonly used. In recent years, interfascial plane blocks like erector spine plane block (ESPB), retrolaminar block (RLB), transverse thoracic plane block, and pectointercostal plane block have been increasingly utilized as important components of acute postoperative pain management in truncal surgeries.

Analysis of Modified ISTH DIC Score in Cases of Abruptio Placentae and Its Correlation with Severity of Abruptio Placentae.

Background: Disseminated intravascular coagulation (DIC) is a potentially fatal condition which is always secondary to an underlying disorder with abruption being the most common cause in obstetrics.Our study analysed the modified International Society of Thrombosis and Haemostasis DIC score for prediction of DIC in cases of abruptio placentae. Additionally, we correlated the score with severity of abruption to optimize its use in limited resource settings.