Publications by authors named "Ashish Uke"

The intricate terrain of breast cancer (BC) in India is examined in this review, which also looks at screening techniques, geographical differences, epidemiological trends, and obstacles to early diagnosis. BC has a major impact in India, especially on women. The research examines data from 2014 to 2024 and finds that, although overall cancer rates are declining, there has been a noticeable increase in BC cases.

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BACKGROUND Diffuse intrinsic pontine glioma represent approximately 10% to 20% of all pediatric central nervous system tumors. Classic brain stem symptoms are cranial nerve deficits, long tract signs, ataxia, alone or in combination. Focal radiotherapy has been the standard of care in patients with diffuse intrinsic pontine gliomas with minimum response.

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Article Synopsis
  • The review examines global regulations and guidelines related to high-dose rate (HDR) brachytherapy aimed at minimizing radiation hazards, highlighting key reports from major organizations like ICRP, IAEA, AAPM, NRC, and AERB.
  • It organizes safety standards into three main categories: layout (structure and design), equipment (installation and performance), and source (usage and security of sealed sources).
  • IAEA's comprehensive guidance serves as a foundational reference for worldwide radiation protection, while AERB establishes regulatory standards for radiation facilities specifically in India.
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The case report details the adaptive radiotherapy management of a 75-year-old female diagnosed with high-grade endometrial carcinoma. The patient, who was known to be hypertensive with no other comorbidities and no family history of cancer, presented with a complaint of bleeding per vagina for six months. Following extensive investigations, she underwent a laparoscopic radical hysterectomy.

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As systemic therapies, alongside radiation, for cancer treatment continue to evolve, the radiation oncology community is facing an increasing number of reirradiation (re-RT) of tumor sites subject to recurrences. There are multiple factors associated with choosing re-RT as a treatment option for a previously irradiated site. The factors include the site of previous radiotherapy (RT), the current extent of the disease, the nature of recurrence, the technique used for previous irradiation, and the previous RT details including dose and dose fractionation.

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Article Synopsis
  • Cervical cancer in India is highly prevalent with a low average age of recurrence, typically treated with concurrent chemoradiotherapy, but options diminish if the cancer returns.
  • The review identifies three categories of prognostic factors: disease-related (tumor characteristics), patient-related (overall health and demographics), and treatment-related (treatment techniques and quality assurance).
  • Key significant factors influencing prognosis include tumor size, stage, nodal status, and nutritional status, while the treatment delivery techniques for radiation therapy were found to be less impactful.
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In recent times, technological advancements have remarkably improved picture archiving and communication system (PACS) capabilities beyond their conventional use in radiology departments. Researchers and instructors have started employing PACS functionalities to improve medical research processes, promote interdisciplinary collaborations, and facilitate learning. To illustrate this point further, the PACS enables researchers to handle and analyze huge amounts of imaging data with superior precision and speed, supporting innovative studies in areas like disease progression, treatment outcomes, and imaging modalities.

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