Publications by authors named "Ashish Neve"
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflammatory lesions, which affect skin and hair follicles in intertriginous areas. HS has a multifactorial aetiology resulting in barrier dysfunction associated with aberrant immune activation. There is increased evidence for the role of inflammasomes in the pathophysiology of inflammatory skin diseases, including HS.
View Article and Find Full Text PDFCancer cells often adapt to targeted therapies, yet the molecular mechanisms underlying adaptive resistance remain only partially understood. Here, we explore a mechanism of RAS/RAF/MEK/ERK (MAPK) pathway reactivation through the upregulation of RAF isoform (RAFs) abundance. Using computational modeling and in vitro experiments, we show that the upregulation of RAFs changes the concentration range of paradoxical pathway activation upon treatment with conformation-specific RAF inhibitors.
View Article and Find Full Text PDFArticle Synopsis
- KSR1 is a scaffolding protein involved in the RAS-RAF-MEK-ERK signaling pathway, which is often altered in cancers and plays a role in mutant RAS-mediated transformation.
- Research shows that when KSR1 is knocked out in BRAFV600E-transformed melanoma cells using CRISPR/Cas9, it leads to issues like slower growth, defects in the cell cycle, and increased cell death.
- The study indicates that KSR1 helps ERK phosphorylate proteins that promote cell survival; without KSR1, there's activation of another pathway (p38 MAPK) that contributes to these negative effects.