Publications by authors named "Ashish Narula"
Article Synopsis
- - STUMP, or stromal tumour of uncertain malignant potential, is a rare condition that is difficult to diagnose and manage due to its vague symptoms and unpredictable behavior.
- - A case study of a 64-year-old man revealed mild urinary issues and a slightly elevated prostate-specific antigen (PSA) level, leading to an MRI that indicated a suspicious area in the left seminal vesicle.
- - Subsequent biopsy confirmed the presence of STUMP along with a Gleason 3+3=6 adenocarcinoma in the prostate, which was treated with robotic-assisted laparoscopic radical prostatectomy and local excision.
The purpose is to report the United Kingdom's largest single-centre experience of robotically assisted laparoscopic radical prostatectomies (RALP), using the neurovascular structure-adjacent frozen-section (NeuroSAFE) technique. We describe the utilisation and outcomes of this technique. This is a retrospective study from 2012 to 2019 on 520 patients undergoing NeuroSAFE RALP at our Institution.
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- - The study examined the unclear causes of stenoses (narrowing) in arteriovenous fistulas (AVFs) used for dialysis, focusing on comparing ultrasound results with histological (microscopic) findings in patients.
- - Ultrasound revealed varying degrees of intimal thickening at the stenosis sites, ranging from 0% to 100%, and showed differences between stenoses with and without neointimal hyperplasia (excess tissue growth).
- - Histological analysis highlighted that AVF stenoses vary significantly, showing different types of tissue changes (such as neointimal hyperplasia and fibrosis), indicating that these stenoses are not uniform and suggesting a need for more research to inform treatment options.
Article Synopsis
- - The study assessed the effectiveness of the NeuroSAFE technique during robot-assisted laparoscopic radical prostatectomy (RALP) in British men, analyzing data from 417 procedures over several years.
- - Results showed that patients in the NeuroSAFE group had higher-risk prostate cancer but achieved better outcomes, including lower rates of positive surgical margins and higher rates of postoperative potency and continence.
- - Overall, the findings suggest that the NeuroSAFE technique resulted in improved surgical and functional results compared to traditional nerve-sparing approaches without NeuroSAFE.
Background: Silicone implants are being used increasingly worldwide, especially in breast augmentation procedures. The most common morbidity observed is capsular contracture, which occurs in 15 percent of cases. To overcome this problem, the authors have developed a novel nanocomposite based on polyhedral oligomeric silsesquioxane-poly(carbonate-urea)urethane (POSS-PCU) for use as tissue implants.
View Article and Find Full Text PDFSignificance of mucin stain in differentiating benign and malignant lesions of prostate.
Indian J Pathol Microbiol
October 2003
Article Synopsis
- * Neutral mucin (PAS positive) was predominantly found in benign lesions (93.3%) compared to 36% in prostate cancer, while acid mucin (AB positive) was more common in cancer cases (68%) than in benign ones (16%).
- * The presence of acid mucin was more pronounced in well-differentiated tumors and decreased in high-grade malignancies, with luminal positivity being slightly higher than cytoplasmic positivity for both types of mucin.