Publications by authors named "Ashish Kumar Agrarwal"
Harnessing Potential of ω-3 Polyunsaturated Fatty Acid with Nanotechnology for Enhanced Breast Cancer Therapy: A Comprehensive Investigation into ALA-Based Liposomal PTX Delivery.
Rohit Kumar Anurag Kumar Dharmendra Kumar Sneha Yadav Neeraj Kumar Shrivastava Ashish Kumar Agrarwal
Pharmaceutics
July 2024
Article Synopsis
- Our study tested whether adding alpha-linolenic acid (ALA) to liposomes with the cancer drug Paclitaxel (PTX) could improve how much the cells absorb the drug, reduce the required dosage, and lessen side effects.
- We created and analyzed ALA-based liposomes, finding that while ALA slightly increased their size, it did not significantly affect how much PTX they could carry, and they released the drug steadily.
- Results showed that ALA-PTX liposomes were taken up more by cells compared to regular PTX liposomes, resulting in better cancer-fighting efficacy, especially against MCF-7 cells, with more noticeable cancer cell death.