Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE.

Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised individuals. However, the cellular mechanisms underlying these defects, as well as the contribution of disease-induced cellular abnormalities, remain largely unexplored. In this study, we conducted a comprehensive serological and cellular analysis of patients with autoimmune systemic lupus erythematosus (SLE) who received the Wuhan-Hu-1 monovalent mRNA coronavirus disease 2019 vaccine.

Understanding the impact of elevated CO and O on growth and yield in Indian wheat cultivars: Implications for food security in a changing climate.

The pressing issue of increasing tropospheric ozone (O) levels necessitates the development of effective stress management strategies for plant protection. While considerable research has elucidated the adverse impacts of O, understanding the combined effects of O and CO requires further investigation. This study focuses on assessing the response of stomatal O flux under various O and CO treatments, individually and in combination, and their repercussions on physiological, growth, and yield attributes in two Indian wheat cultivars, HUW-55 and PBW-550, which exhibit varying levels of sensitivities against elevated O.

Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus.

The emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.

Advancements in Rechargeable Zn-Air Batteries with Transition-Metal Dichalcogenides as Bifunctional Electrocatalyst.

This review covers recent progress on transition metal dichalcogenides (TMDs) as bifunctional electrocatalysts for Zinc-air batteries (ZABs), emphasizing their suitable surface area, electrocatalytic active sites, stability in acidic/basic environments, and tunable electronic properties. It discusses strategies like defect engineering, doping, interface, and structural modifications of TMDs nanostructures for enhancing the performances of ZABs. Zinc-air batteries are promising energy storage devices owing to their high energy density, low cost, and environmental friendliness.

Divergent responses of ascorbate and glutathione pools in ozone-sensitive and ozone-tolerant wheat cultivars under elevated ozone and carbon dioxide interaction.

Crop plants face complex tropospheric ozone (O) stress, emphasizing the need for a food security-focused management strategy. While research extensively explores O's harmful effects, this study delves into the combined impacts of O and CO. This study investigates the contrasting responses of O-sensitive (PBW-550) and O-resistant (HUW-55) wheat cultivars, towards elevated ozone (eO) and elevated carbon dioxide (eCO), both individually and in combination.

enhancement of Zika virus infection by preexisting West Nile virus antibodies in human plasma-derived immunoglobulins revealed after P2 binding site-specific enrichment.

Human immunoglobulin preparations contain a diverse range of polyclonal antibodies that reflect past immune responses against pathogens encountered by the blood donor population. In this study, we examined a panel of intravenous immunoglobulins (IGIVs) manufactured over the past two decades (1998-2020) for their capacity to neutralize or enhance Zika virus (ZIKV) infection . These IGIVs were selected specifically based on their production dates in relation to the occurrences of two flavivirus outbreaks in the U.

Ni-Fe/Co-Fe Oxide-MoSe Hybrid Nanostructures as Novel Electrocatalysts for High-Performance Rechargeable Zinc-Air Batteries.

Metal-air batteries can play a crucial role in curbing air pollution due to carbon emission. Here, we report the hydrothermally synthesized bimetal oxides (NiFeO and CoFeO) and their hybrid nanostructures with MoSe as potential electrocatalysts for electrically rechargeable Zn-air batteries. The NiFeO-MoSe hybrid nanostructure exhibits the best electrocatalytic activity (overpotential η ≈ 218 mV and Tafel slope ≈ 37 mV dec) for the OER study among prepared electrocatalysts in 1 M KOH electrolyte.

Large area CVD-grown vertically and horizontally oriented MoS nanostructures as SERS biosensors for single molecule detection.

Surface-enhanced Raman scattering (SERS) has attracted extensive attention for its rapid, ultra-sensitive, non-destructive and label-free fingerprint detection of trace molecules. Recently, two-dimensional transition metal dichalcogenides have been investigated as SERS substrates owing to their low cost, simple synthesis, excellent optical behavior, tunable bandgap, high carrier mobility and good biocompatibility. Here, we have synthesized 2H-MoS nanostructures of different morphologies (vertically and horizontally oriented) the chemical vapor deposition (CVD) method on different substrates (FTO-coated glass, Si and SiO-Si) and utilized them as SERS substrates for the detection of bilirubin and vitamin B biomolecules.

Serum Zinc Level and Efficacy of Zinc Therapy in Cutaneous Leishmaniasis: a Systematic Review and Meta-analysis.

Cutaneous leishmaniasis is a parasitic skin disease prevalent in many parts of the world. Zinc has been investigated for its potential role in the immune response against Leishmania parasites. This study aimed to systematically review the literature and conduct meta-analyses to evaluate the serum zinc level and efficacy of zinc therapy in cutaneous leishmaniasis.

Morphological dependent exciton dynamics and thermal transport in MoSe films.

Thermal transport and exciton dynamics of semiconducting transition metal dichalcogenides (TMDCs) play an immense role in next-generation electronic, photonic, and thermoelectric devices. In this work, we synthesize distinct morphologies (snow-like and hexagonal) of a trilayer MoSe film over the SiO/Si substrate the chemical vapor deposition (CVD) method and investigated their morphological dependent exciton dynamics and thermal transport behaviour for the first time to the best of our knowledge. Firstly, we studied the role of spin-orbit and interlayer couplings both theoretically as well as experimentally first-principles density functional theory and photoluminescence study, respectively.

Combating ozone stress through N fertilization: A case study of Indian bean ( L.).

The present study investigates the efficiency of nitrogen (N) amendments in the management of ozone (O) stress in two varieties (Kashi Sheetal and Kashi Harittima) of Indian bean ( L.). Two O concentrations, ambient (44.

Experimental and Theoretical Investigations of Fe-Doped Hexagonal MnNiGe.

We report a comprehensive investigation of MnNiFeGe Heusler alloy to explore its magnetic, caloric, and electrical transport properties. The alloy undergoes a ferromagnetic transition across ∼ 212 K and a weak-antiferromagnetic transition across ∼ 180 K followed by a spin-glass transition below ∼ 51.85 K.

Hypoxia-driven metabolic heterogeneity and immune evasive behaviour of gastrointestinal cancers: Elements of a recipe for disaster.

Gastrointestinal (GI) cancers refer to a group of malignancies associated with the GI tract (GIT). Like other solid tumors, hypoxic regions consistently feature inside the GI tumor microenvironment (TME) and contribute towards metabolic reprogramming of tumor-resident cells by modulating hypoxia-induced factors. We highlight here how the metabolic crosstalk between cancer cells and immune cells generate immunosuppressive environment inside hypoxic tumors.

Effect of Body Mass Index on the outcomes of primary Total Knee Arthroplasty up to one year - A prospective study.

Background: Obesity is a significant risk factor for developing knee osteoarthritis, and these cases suffer from complications following Total Knee Arthroplasty (TKA). An association between obesity and outcome after TKA is ambiguous. Knowledge is scarce about a definite relation between the two.

Southeast Asian Dipterocarp origin and diversification driven by Africa-India floristic interchange.

The evolution and diversification of ancient megathermal angiosperm lineages with Africa-India origins in Asian tropical forests is poorly understood because of the lack of reliable fossils. Our palaeobiogeographical analysis of pollen fossils from Africa and India combined with molecular data and fossil amber records suggest a tropical-African origin of Dipterocarpaceae during the mid-Cretaceous and its dispersal to India during the Late Maastrichtian and Paleocene, leading to range expansion of aseasonal dipterocarps on the Indian Plate. The India-Asia collision further facilitated the dispersal of dipterocarps from India to similar climatic zones in Southeast Asia, which supports their out-of-India migration.

Laparoscopic Versus Open Rectopexy for Rectal Prolapse: A Randomized Controlled Trial.

Introduction Most of the patients with rectal prolapse complain of fecal incontinence followed by constipation. Surgery is the only definitive treatment option for rectal prolapse. There are two approaches: either transanal/perineal or transabdominal.

Glutamate binding triggers monomerization of unliganded mGluR2 dimers.

The Metabotropic glutamate receptor 2 (mGluR2) is involved in several neurological and psychiatric disorders and is an attractive drug target. It is believed to form a strict dimer and the dimeric assembly is necessary for glutamate induced activation. Although many studies have focused on glutamate induced conformational changes, the dimerization propensity of mGluR2 with and without glutamate has never been investigated.

Large Area Vertically Oriented Few-Layer MoS for Efficient Thermal Conduction and Optoelectronic Applications.

Large area growth of MoS can show great advances in optoelectronic devices due to its unique optical and electronic properties. Here, we directly grow vertically oriented and interconnected few-layer MoS over 1 × 1 cm of p-type Si substrate using CVD technique. We report for the first time the thermal conductivity of vertically oriented few-layer (VFL) MoS using the optothermal Raman technique.

Unstructured loop is essential for the activation of mGluR2.

Metabotropic Glutamate Receptors (mGluRs) are Class C G-protein coupled receptors (GPCRs) that are expressed throughout the central nervous system and are involved in several neurological and psychiatric disorders. Although, many studies focused on Glutamate induced activation of mGluR2, however, the role of unstructured loop (or "BC loop") in activation of metabotropic Glutamate receptors is currently unknown. Here, using Förster Resonance Energy Transfer (FRET) based assay in live cells we show that unstructured loop is required for Glutamate induced conformation and hence the activation of the receptor.

Coupled influence of precipitation and vegetation on millennial-scale erosion rates derived from 10Be.

Water is one of the main agent of erosion in many environmental settings, but erosion rates derived from beryllium-10 (10Be) suggests that a relationship between precipitation and erosion rate is statistically non-significant on a global scale. This might be because of the strong influence of other variables on erosion rate. In this global 10Be compilation, we examine if mean annual precipitation has a statistically significant secondary control on erosion rate.

Neonatal Exposure to Endocrine Disrupting Chemicals Impairs Learning Behaviour by Disrupting Hippocampal Organization in Male Swiss Albino Mice.

Hippocampus is highly susceptible to endocrine disrupting chemicals exposure particularly during the critical phase of brain development. In this study, mice offspring were exposed to endocrine disruptors mancozeb (MCZ) and imidacloprid (IMI) individually (40 mg MCZ and 0.65 mg IMI/kg/day) as well as to their equimixture (40 mg MCZ + 0.

Long-term health-related quality of life in living liver donors: A south Asian experience.

Aim: The aim of this study was to evaluate long-term health-related quality of life (HRQOL), changes in lifestyle, and complications in living liver donors at a single transplant center from southern India.

Methods: A total of 64 consecutive living liver donors from 2008 to 2011 were evaluated; 46 of 64 donors completed the short form 36 (SF-36) via telephonic interviews or clinic consultations. Mean follow-up was 48 months (range: 37-84 months).

Correction: Proton conduction through oxygen functionalized few-layer graphene.

Correction for 'Proton conduction through oxygen functionalized few-layer graphene' by Chanderpratap Singh et al., Chem. Commun.