Publications by authors named "Ashish Gupta"

Introduction: Effective monitoring of insect-pests is vital for safeguarding agricultural yields and ensuring food security. Recent advances in computer vision and machine learning have opened up significant possibilities of automated persistent monitoring of insect-pests through reliable detection and counting of insects in setups such as yellow sticky traps. However, this task is fraught with complexities, encompassing challenges such as, laborious dataset annotation, recognizing small insect-pests in low-resolution or distant images, and the intricate variations across insect-pests life stages and species classes.

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Avian reoviruses (ARVs) are ubiquitous and play a role in diseases affecting various organs in chickens and turkeys. In recent years, tenosynovitis and lameness emerged as the most frequently reported clinical conditions. In this report, we describe a case of neurological disease associated with ARV infection in 4-week-old turkeys in Alberta.

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Alzheimer's disease (AD) is a chronic neurological disorder that impacts the elderly population all over the globe. Evidence suggests association between AD and metabolic disorders such as diabetes mellitus (DM) and obesity (OB). The present study is an attempt to evaluate metabolic alterations in the serum and brain through NMR spectroscopy with the aim to identify shared metabolic signatures.

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Importance: Missed diagnosis can lead to preventable patient harm.

Objective: To develop and implement a portfolio of electronic triggers (e-triggers) and examine their performance for identifying missed opportunities in diagnosis (MODs) in emergency departments (EDs).

Design, Setting, And Participants: In this retrospective medical record review study of ED visits at 1321 Veterans Affairs health care sites, rules-based e-triggers were developed and implemented using a national electronic health record repository.

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Rapid changes in consumer preferences for high-quality animal-based protein have driven the poultry industry to identify non-invasive, in-line processing technologies for rapid detection of muscle meat quality defects. At production plants, technologies like radio-frequency waves (RF waves) can identify and separate myopathy-conditioned meat, reducing misclassification errors due to human fatigue and inexperience. Previous studies have shown that advanced diagnostic tools combined with complex data analytics, such as support vector machines (SVMs) and backpropagation neural networks (BPNNs), can classify chicken breast myopathies post-deboning.

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Background: Ethical conduct of research depends on the voluntary expression of consent and adequate disclosure of information about the research in informed consent documents (ICDs).

Objectives: The objective of this study was to analyze ICDs of academic studies for compliance with National Ethical Guidelines for Biomedical and Health Research laid down by the Indian Council of Medical Research (ICMR) and to determine the readability of ICDs using the Flesch-Kincaid Grade Level scale and Flesch reading-ease (FRE) score.

Methodology: ICDs of academic research projects submitted during 2020-22 were retrieved from the IEC office and analyzed for compliance with ICMR 2017 guidelines.

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Background: Due to the ageing population, the number of symptomatic degenerative rotator cuff tears has increased substantially, and some are challenging to repair due to poor tendon quality with significant retraction. In order to optimize repair integrity and function, rotator cuff repair reinforcement with a superior capsule reconstruction has been proposed. This study presents the results of a technique combining cuff repair and capsular reconstruction (CRACR) using acellular dermal allograft in patients with massive rotator cuff tears and retears.

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: Proximal humeral bone deficiency in revision shoulder arthroplasty is an emerging and challenging problem as the use of reverse shoulder arthroplasty (RSA) increases. This paper presents a technical note discussing our detailed preoperative planning steps, surgical techniques, and their rationale in carrying out the use of an allograft prosthetic composite (APC) to address proximal humeral bone deficiency in revision RSA. The outcomes of this technique are also presented.

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Acromegaly due to ectopic secretion of growth hormone-releasing hormone (GHRH) is a rare disorder. The signs and symptoms of ectopic acromegaly are indistinguishable from acromegaly due to a somatotroph adenoma. A 35-year-old female presented with secondary amenorrhea for 10 years, intermittent headache, and reduced vision in both eyes for 4 years, which worsened over 4 months before presentation.

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Mucormycosis is an invasive fungal infection caused by fungi of the order Mucorales. During the coronavirus disease 2019 (COVID-19), a rise in the number of COVID-19-associated mucormycosis (CAM) patients was reported globally. Cutaneous mucormycosis is the third most common presentation of mucormycosis.

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Background: Cerebral adrenoleukodystrophy is a severe form of X-linked adrenoleukodystrophy characterized by white-matter disease, loss of neurologic function, and early death. Elivaldogene autotemcel (eli-cel) gene therapy, which consists of autologous CD34+ cells transduced with Lenti-D lentiviral vector containing complementary DNA, is being tested in persons with cerebral adrenoleukodystrophy.

Methods: In a phase 2-3 study, we evaluated the efficacy and safety of eli-cel therapy in boys with early-stage cerebral adrenoleukodystrophy and evidence of active inflammation on magnetic resonance imaging (MRI).

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Article Synopsis
  • Gene therapy using elivaldogene autotemcel (eli-cel) has shown effectiveness in treating cerebral adrenoleukodystrophy but raises concerns about cancer risks.
  • Research analyzed blood and bone marrow samples from patients who received eli-cel to evaluate integration sites and other genetic factors.
  • Out of 67 patients treated, 7 developed hematologic cancers, with multiple instances linked to lentiviral vector insertions, though some patients successfully underwent stem cell transplantation and remained symptom-free.
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Eosinophils are recruited to the heart during acute myocardial infarction (MI) and are considered part of the inflammatory response associated with adverse clinical outcomes. We assessed the impact of eosinopenia on cardiac imaging biomarkers in patients presenting with ST-segment elevation MI. This is a post-hoc analysis of the Evaluating the effectiveness of intravenous Ciclosporin on reducing reperfusion injury in pAtients undergoing PRImary percutaneous coronary intervention (CAPRI) trial.

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Article Synopsis
  • In early 2021, foliar blight symptoms were found on Chinese cabbage at a research farm in Tripura, India, affecting 5-10% of the plants, characterized by grayish water-soaked lesions.
  • Samples from the infected plants were treated, cultured, and examined microscopically, revealing mycelium with distinct characteristics attributed to the fungus Rhizoctonia solani.
  • Genetic sequencing of the isolates confirmed their identity as R. solani, showing high similarity with existing sequences in GenBank, and the isolates were deposited in the Indian Type Culture Collection.
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  • The study investigated the significance of mean platelet volume (MPV) and MPV-to-lymphocyte ratio (MPVLR) in diagnosing and predicting outcomes in acute coronary syndrome (ACS) among Indian patients, as this area hasn't been thoroughly explored.
  • Conducted from 2020 to 2022 with 110 ACS cases and matched controls, the research revealed that both MPV and MPVLR levels were significantly higher in ACS patients compared to controls and correlated with the severity of ACS and hospital outcomes.
  • The findings suggest that while MPV and MPVLR could help differentiate between cardiac and noncardiac chest pain in clinical settings, MPV is a more reliable predictor of inhospital mortality than MPVLR.
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Background: Primary glenohumeral osteoarthritis in young patients poses challenging treatment decisions. Arthroplasty options have different failure profiles and implant survivorship patterns. This registry study aims to analyze the cumulative per cent revision (CPR) rate of different types of arthroplasties conducted for primary osteoarthritis in patients below 55 years of age.

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Introduction: Gibbus deformity has been documented as a common musculoskeletal abnormality in mucopolysaccharidosis type I (Hurler syndrome, MPS IH), and its recognition often leads to the diagnosis of MPS IH. While the incidence has been described, the progression of gibbus deformities is not well known. Here we describe the natural history of gibbus deformity in a single center patient population using serial spinal MRI scans.

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Article Synopsis
  • * A new method combines the Parametric Equation of Motion (PEM) with nuclear charge stabilization to accurately identify the true LUMO, addressing challenges posed by extra diffuse functions in the basis set that can lead to avoided crossings.
  • * This modified PEM effectively distinguishes the true LUMO by preventing the stabilization of problematic states and does so with minimal computational resources.
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This meta-analysis review undertakes a comprehensive examination of various approaches for identifying myopathic fillets and meticulously evaluates the effects of bird age, deboning time, and different cooking and storage conditions on woody breast (WB) myopathic conditions in broiler deboned fillets. The data, meticulously collected from 20 articles based on predefined inclusion criteria sourced from various databases and online resources, reveal significant insights. For instance, the analysis uncovers that deboning time significantly affects Meullenet-Owens Razor Shear (MORS), Blunt Meullenet-Owens Razor Shear (BMORS), and descriptive analysis values ( < 0.

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PF1 + 2 plasma levels are a crucial indicator for assessing anticoagulant action in individuals receiving anticoagulant treatment. Urine also has PF1 + 2 levels due to its molecular size. Hence, the present study aims to measure urinary prothrombin fragment 1 + 2 (uPF1 + 2) in patients taking anticoagulants in order to divulge a noninvasive surrogate marker of PT-INR of blood coagulopathy.

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Synopsis of recent research by authors named "Ashish Gupta"

  • - Ashish Gupta's recent research encompasses diverse medical fields, focusing on innovative surgical techniques and treatments, such as the use of Allograft Prosthetic Composite (APC) in revision shoulder arthroplasty and lentiviral gene therapy for cerebral adrenoleukodystrophy.
  • - His work highlights the ongoing challenges in diagnosing and treating rare conditions, including recognizing ectopic acromegaly and COVID-19-associated mucormycosis, reflecting the critical intersection of infectious diseases with complications from other health issues.
  • - Gupta's publications further delve into the implications of emerging technologies in medicine, such as the application of deep learning in orthopaedics to enhance diagnostic accuracy, demonstrating a commitment to advancing clinical practice through research.