Context: Nano-calcium hydroxide (NCH) has been proven to have several advantages over normal calcium hydroxide, supporting in its possible use as an intracanal medicament.
Aim: The aim is to evaluate and compare calcium ion release and pH change using NCH with different vehicles as intracanal medicament.
Subjects And Methods: Sixty freshly extracted premolars were decoronated at the cementoenamel junction level and the length was standardized.