Publications by authors named "Ashik Gurung"
Article Synopsis
- Chronic exposure to cocaine leads to lasting changes in the brain's genetic structure, particularly in the nucleus accumbens, which plays a key role in motivation and addiction.
- After withdrawing from cocaine, the depletion of a specific histone variant (H2A.Z) occurs, resulting in increased gene expression linked to relapse behavior among certain neurons (D1 MSNs).
- The study highlights how the chaperone ANP32E regulates H2A.Z removal, suggesting potential therapeutic targets for preventing the negative effects of cocaine on brain function and behavior.
Cocaine use disorder (CUD) is a chronic neuropsychiatric condition that results from enduring cellular and molecular adaptations. Among substance use disorders, CUD is notable for its rising prevalence and the lack of approved pharmacotherapies. The nucleus accumbens (NAc), a region that is integral to the brain's reward circuitry, plays a crucial role in the initiation and continuation of maladaptive behaviors that are intrinsic to CUD.
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