Publications by authors named "Ashi Mittal"
Article Synopsis
- Scientists created a new mouse model to study alcohol-associated hepatitis (AAH) that is more similar to humans than older models.
- They fed male mice a special diet containing alcohol and a chemical called thioacetamide for 12 weeks to induce liver damage.
- The results showed that these mice had major signs of liver problems, inflammation, and changes in gut bacteria, making it a better tool to study AAH compared to other methods.
Reactive oxygen species (ROS) are powerful weapons for various anticancer therapies. However, high glutathione (GSH) levels in cancer cells can significantly reduce the efficacy of such therapies. In this study, pH-responsive fluorescein-encapsulated zeolitic imidazolate framework-8 nanoparticles were synthesized for ROS-mediated combination therapy.
View Article and Find Full Text PDFNumerous studies have shown that nanosized zeolitic imidazolate framework particles (ZIF-8 NPs) serve as promising vehicles for pH-responsive drug delivery. An understanding of their interaction with serum proteins present in physiological systems will thus be of critical importance. In this work, monodisperse ZIF-8 NPs with an average size of 60 nm were synthesized at room temperature and characterized for their various physicochemical properties.
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