Publications by authors named "Asher Emanuel"
Spinal cord ischemia can lead to paralysis or paraparesis, but if detected early it may be amenable to treatment. Current methods use evoked potentials for detection of spinal cord ischemia, a decades old technology whose warning signs are indirect and significantly delayed from the onset of ischemia. Here we introduce and demonstrate a prototype fiber optic device that directly measures spinal cord blood flow and oxygenation.
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- The study aimed to determine if overexpressing the antioxidant enzyme SOD1 provides protection against endotoxic shock in mice and how genetic background influences this effect.
- Transgenic mice overexpressing human SOD1 were compared to control mice across different genetic backgrounds, and their survival rates after induced endotoxic shock were measured.
- Results showed that while overexpressed SOD1 activity was higher in both transgenic strains, only the tg-TX group exhibited significantly improved survival compared to their controls, whereas tg-JAX mice did not show any survival advantage likely due to reduced endogenous SOD1 activity.