Preanaesthetic blood tests in cats and dogs older than 8 years: anaesthetists' prediction and peri-anaesthetic changes.

Objective: To evaluate the anaesthetist's ability to predict abnormalities in preanaesthetic blood test results obtained from cats and dogs older than 8 years and to describe the impact of these preanaesthetic blood test results on the American Society Anesthesiologists (ASA) physical status classification, anaesthetic protocol and procedures.

Study Design: Observational, prospective, clinical multi-centre study.

Animals: A total of 333 cats and dogs.

Comparison of two topical treatments of gastro-oesophageal regurgitation in dogs during general anaesthesia.

Objective: To determine whether suction, lavage and instillation of sodium bicarbonate, following a gastro-oesophageal regurgitation event under general anaesthesia, would alter oesophageal pH to a greater degree than when lavage was not used.

Study Design: Prospective, randomised, clinical study.

Animals: A group of 22 client-owned dogs.

Opioid-sparing effect of a medetomidine constant rate infusion during thoraco-lumbar hemilaminectomy in dogs administered a ketamine infusion.

Objective: To evaluate the perioperative opioid-sparing effect of a medetomidine (MED) infusion compared to a saline (SAL) infusion in otherwise healthy dogs undergoing thoraco-lumbar hemilaminectomy surgery.

Study Design: Randomized, partially blinded, clinical study.

Animals: A total of 44 client-owned adult dogs.

Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9.

We report for the first time that expression of the novel IL-1 cytokine receptor IL-1Rrp2 (IL-1R6) is unique to DCs within the human myelomonocytic lineage. IL-1Rrp2 was expressed by monocyte-derived dendritic cells (MDDCs) which was dose-dependently increased by IL-4 and correlated with increased numbers of differentiated MDDCs. Human plasmacytoid DCs also express IL-1Rrp2 but the receptor is not expressed by either myeloid DC type 1 (mDC1) or mDC2 cells.