Publications by authors named "Asha Sarah Eapen"
Article Synopsis
- - Identifying noninvasive biomarkers for head and neck cancers, especially salivary gland cancers, is challenging, but the tumor secretome may provide valuable information.
- - Research shows that the cancer secretome from salivary gland tumors can enhance the expression of key biomarkers (bone sialoprotein and dentin sialoprotein) in normal salivary gland cells.
- - The cancer secretome could influence normal cell behavior, possibly aiding cancer progression by altering critical cellular processes related to cancer survival and metastasis.
Dentin Matrix Protein 1 (DMP1) plays a regulatory role in dentin mineralization and can also function as a signaling molecule. MMP-2 (matrix metalloproteinase-2) is a predominant protease in the dentin matrix that plays a prominent role in tooth formation and a potential role during the carious process. The possibility that MMP-2 can cleave DMP1 to release biologically active peptides was investigated in this study.
View Article and Find Full Text PDFDentin matrix protein 1 (DMP1), a phosphorylated protein present in the mineral phase of both vertebrates and invertebrates, is a key regulatory protein during biogenic formation of mineral deposits. Previously we showed that DMP1 is localized in the nuclear compartment of preosteoblasts and preodontoblasts. In the nucleus DMP1 might play an important role in the regulation of genes that control osteoblast or odontoblast differentiation.
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