A 20-year analysis of gender trends in oncology authorship in the Cochrane database of systematic reviews.

Objectives: The objective of this study was to evaluate global longitudinal publication trends in oncology in the Cochrane Database of Systematic Reviews (CDSR) from 2001-2020.

Design: Retrospective bibliometric analysis.

Primary And Secondary Outcome Measures: The primary outcome measures were the numbers and percentages of women as first, last, and corresponding author across all CDSR oncology publications.

A CHip off the old block.

Lineage-specific effects of upstream promoters affect ST2 expression and effector function in T1 cells.

Promoting (and targeting) alternative expression.

Lineage-specific effects of upstream promoters affect ST2 expression and effector function in T1cells.

Everything everywhere all at once.

In successful melanoma immunotherapy, clonal TCRs can recognize multiple tumor-specific antigens simultaneously through cross-reactivity.

Macs-imizing sepsis protection.

CD169 macrophage-intrinsic IL-10 production mitigates mortality from sepsis.

Taking the STING out.

ABCC1 is an ATP-dependent cGAMP exporter responsible for negatively regulating STING signaling.

Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer.

Co-occurrent KRAS and TP53 mutations define a majority of patients with pancreatic ductal adenocarcinoma (PDAC) and define its pro-metastatic proclivity. Here, we demonstrate that KRAS-TP53 co-alteration is associated with worse survival compared with either KRAS-alone or TP53-alone altered PDAC in 245 patients with metastatic disease treated at a tertiary referral cancer center, and validate this observation in two independent molecularly annotated datasets. Compared with non-TP53 mutated KRAS-altered tumors, KRAS-TP53 co-alteration engenders disproportionately innate immune-enriched and CD8 T-cell-excluded immune signatures.

Immune gains through brain drains.

In a mouse model of pneumococcal meningitis, skull channels provide extravascular signaling to the skull marrow capable of initiating local marrow hematopoiesis.

CyTOF for the Masses.

Mass cytometry has revolutionized immunophenotyping, particularly in exploratory settings where simultaneous breadth and depth of characterization of immune populations is needed with limited samples such as in preclinical and clinical tumor immunotherapy. Mass cytometry is also a powerful tool for single-cell immunological assays, especially for complex and simultaneous characterization of diverse intratumoral immune subsets or immunotherapeutic cell populations. Through the elimination of spectral overlap seen in optical flow cytometry by replacement of fluorescent labels with metal isotopes, mass cytometry allows, on average, robust analysis of 60 individual parameters simultaneously.

Executive CoAching unleashes Tc22 anti-tumor capacity.

CoA-driven mitochondrial metabolism enhances the anti-tumor properties of IL-22–producing CD8 T cells.

Turning the Tide for Academic Women in STEM: A Postpandemic Vision for Supporting Female Scientists.

The "leaky pipeline" of women in science, technology, engineering, and mathematics (STEM), which is especially acute for academic mothers, continues to be problematic as women face continuous cycles of barriers and obstacles to advancing further in their fields. The severity and prevalence of the COVID-19 pandemic both highlighted and exacerbated the unique challenges faced by female graduate students, postdocs, research staff, and principal investigators because of lockdowns, quarantines, school closures, lack of external childcare, and heightened family responsibilities, on top of professional responsibilities. This perspective provides recommendations of specific policies and practices that combat stigmas faced by women in STEM and can help them retain their careers.

A T-rojan horse strategy for cancer immunotherapy.

CDK4/6 inhibitor-treated breast cancer cells recruit T cells via metabolic stress-induced chemokines.

B careful: Humoral responses and COVID-19 severity.

Neutralizing antibody responses to SARS-CoV-2, though often of limited longevity, have generally been assumed to be protective against COVID-19 disease.

Finding Camel-ot: A Holy Grail against pandemic SARS-CoV-2?

Engineered camelid antibody multimers can potently block SARS-CoV-2 viral entry.

Expansion and CD2/CD3/CD28 stimulation enhance Th2 cytokine secretion of human invariant NKT cells with retained anti-tumor cytotoxicity.

Background Aims: Key obstacles in human iNKT cell translational research and immunotherapy include the lack of robust protocols for dependable expansion of human iNKT cells and the paucity of data on phenotypes in post-expanded cells.

Methods: We delineate expansion methods using interleukin (IL)-2, IL-7 and allogeneic feeder cells and anti-CD2/CD3/CD28 stimulation by which to dependably augment Th2 polarization and direct cytotoxicity of human peripheral blood CD3Vα24Vβ11 iNKT cells.

Results: Gene and protein expression profiling demonstrated augmented Th2 cytokine secretion (IL-4, IL-5, IL-13) in expanded iNKT cells stimulated with anti-CD2/CD3/CD28 antibodies.

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E.

The intestine is the home to the largest number of immune cells in the body. The small and large intestinal immune systems police exposure to exogenous antigens and modulate responses to potent microbially derived immune stimuli. For this reason, the intestine is a major target site of immune dysregulation and inflammation in many diseases including but, not limited to inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, graft-versus-host disease (GVHD) after bone marrow transplantation (BMT), and many allergic and infectious conditions.

If you build it, they will come: Reaching across the "IL" with Neo-2/15.

A computationally designed mimic of interleukin-2 (IL-2) selectively expands cytotoxic CD8 T cells over regulatory T cells and supports antitumor immunity.

Innate Immune Determinants of Graft-Versus-Host Disease and Bidirectional Immune Tolerance in Allogeneic Transplantation.

The success of tissue transplantation from a healthy donor to a diseased individual (allo-transplantation) is regulated by the immune systems of both donor and recipient. Developing a state of specific non-reactivity between donor and recipient, while maintaining the salutary effects of immune function in the recipient, is called "immune (transplantation) tolerance". In the classic early post-transplant period, minimizing bidirectional donor ←→ recipient reactivity requires the administration of immunosuppressive drugs, which have deleterious side effects (severe immunodeficiency, opportunistic infections, and neoplasia, in addition to drug-specific reactions and organ toxicities).

cROSs-presentation in pDCs: An energetic (m)CAT and mouse game.

pDC cross-presentation of antigens to CD8 T cells depends on mitochondrial generation of reactive oxygen species.

Bigger and better in Tex's.

High-dimensional profiling defines novel metrics of T cell exhaustion in HIV and cancer.