Graphene oxide nanoribbons conjugated with 1, 2-distearoyl-sn-glycero-3 phosphoethanolamine-poly (ethylene glycol)-transferrin enhanced targeted delivery and cytotoxicity of raloxifene against breast cancer.

The clinical utility of raloxifene (RLX), a selective estrogen receptor modulator (SERM), has been compromised by severe side effects and unfavorable drug properties. To address these, a transferrin (Tf) conjugated graphene oxide nanoribbon (GONR) platform was tried for RLX. The stability of GONRs in biological media was improved by surface modification with 1, 2-Distearoyl-sn-glycero-3 phosphoethanolamine-Poly (ethylene glycol) (DSPE-PEG).

An Update on Emergent Nano-Therapeutic Strategies against Pediatric Brain Tumors.

Pediatric brain tumors are the major cause of pediatric cancer mortality. They comprise a diverse group of tumors with different developmental origins, genetic profiles, therapeutic options, and outcomes. Despite many technological advancements, the treatment of pediatric brain cancers has remained a challenge.

Oral insulin delivery: Barriers, strategies, and formulation approaches: A comprehensive review.

Diabetes Mellitus is characterized by a hyperglycemic condition which can either be caused by the destruction of the beta cells or by the resistance developed against insulin in the cells. Insulin is a peptide hormone that regulates the metabolism of carbohydrates, proteins, and fats. Type 1 Diabetes Mellitus needs the use of Insulin for efficient management.

Bioinspired and biomimetic micro- and nanostructures in biomedicine.

Bioinspired and biomimetic micro- and nanostructures have a high significance in the field of biomedicine. In this review, the possible applications of these micro- and nanostructures that come across in our daily life and inspired by nature itself are presented. Also, the biomimetic and bioinspired systems related to micro- and nanostructures in biomedicine are also described.

Carbon Nanotubes: Current Perspectives on Diverse Applications in Targeted Drug Delivery and Therapies.

Current discoveries as well as research findings on various types of carbon nanostructures have inspired research into their utilization in a number of fields. These carbon nanostructures offer uses in pharmacy, medicine and different therapies. One such unique carbon nanostructure includes carbon nanotubes (CNTs), which are one-dimensional allotropes of carbon nanostructure that can have a length-to-diameter ratio greater than 1,000,000.

Strategies to Improve Insulin Delivery through Oral Route: A Review.

Diabetes mellitus is found to be among the most suffered and lethal diseases for mankind. Diabetes mellitus type-1 is caused by the demolition of pancreatic islets responsible for the secretion of insulin. Insulin is the peptide hormone (anabolic) that regulates the metabolism of carbohydrates, fats, and proteins.

Graphene nanoribbon: An emerging and efficient flat molecular platform for advanced biosensing.

Graphene nanoribbons (GNRs) are lengthened one-dimensional monolayer strips of graphene and have a hexagonal honeycomb lattice structure. The captivating properties like electrical conductivity, emerging band gap, optical property, thermal conductivity, high mechanical strength, and ultrahigh surface area make them a better candidate for biomedical applications. The properties can be significantly reformed and controlled by altering the edge functionalities and geometry.

Advanced drug delivery applications of layered double hydroxide.

Layered double hydroxides (LDHs), also known as anionic clays or hydrotalcite-like compounds, are a class of nanomaterials that attained great attention as a carrier for drug delivery applications. The lamellar structure of this compound exhibits a high surface-to-volume ratio which enables the intercalation of therapeutic agents and releases them at the target site, thereby reducing the adverse effect. Moreover, the intercalated drug can be released in a sustained manner, and hence the frequency of drug administration can be decreased.

Graphene nanoribbons: A promising nanomaterial for biomedical applications.

Graphene nanoribbons (GNRs) are narrow lengthened strips of single-layer graphene. Among the graphene family of nanomaterials, GNRs are remarkable materials due to their attractive physical, chemical, electrical, mechanical, thermal, and optical properties. They have an ultra-high surface area.