Diuretics - a panacea for acute heart failure? Different formulations, doses, and combinations.

Diuretics have been the cornerstone of acute heart failure (AHF) therapy for >200 years, although the treatment of chronic heart failure has changed dramatically over the past decades with the introduction of angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, beta-blockers, and aldosterone inhibitors. These treatment modalities were never tested prospectively in the acute setting. Furthermore, there is a significant lack of prospective data on the use of diuretics in both chronic (CHF) and AHF.