Publications by authors named "Ash Nerurkar"
Article Synopsis
- * The research involved profiling samples from 84 patients using various analyses, revealing nine genes whose amplification is linked to poor AI response, particularly highlighting the gene CHKA.
- * The findings suggest that CHKA influences estrogen receptor-driven cancer processes and can potentially be explored further as a key player in resistance mechanisms against AIs.
Oestrogen receptor (ER) negative breast cancers are more likely to achieve a pathological complete response (pCR) to neoadjuvant chemotherapy compared to those with ER positive tumours. ER positive tumours exhibit low proliferation and ER negative cancers high proliferation. The aim of this study was to determine to what extent the better response of ER negative cancers correlates with proliferation rate.
View Article and Find Full Text PDFPurpose: To compare the prognostic significance of proliferation, as assessed by Ki67 expression, in breast cancer before and after neoadjuvant chemotherapy.
Methods: A retrospective search of a prospectively maintained clinical database was performed to identify patients treated with neoadjuvant chemotherapy at the Royal Marsden Hospital. The expression of Ki67 was assessed using immunohistochemistry in pre-therapy core-needle biopsy and post-therapy surgical excision specimens.