A systematic review of clinical studies of electrical stimulation for treatment of lower urinary tract dysfunction.

Introduction And Hypothesis: The aim of this manuscript was to provide a systematic literature review of clinical trial evidence for a range of electrical stimulation therapies in the treatment of lower urinary tract symptoms (LUTS).

Methods: The databases MEDLINE, BIOSIS Previews, Inside Conferences, and EMBASE were searched. Original clinical studies with greater than 15 subjects were included.

Duloxetine compared with placebo for the treatment of women with mixed urinary incontinence.

Aims: Evaluate duloxetine in the treatment of women with mixed urinary incontinence (MUI).

Materials And Methods: 588 women, 19-85 years old with >or=4 incontinence episodes/week were randomly assigned to duloxetine 80 mg/day (N = 300) or placebo (N = 288). Patients were classified into three symptom subgroups: stress or urge predominant MUI (SPMUI or UPMUI) or balanced MUI (BMUI) based on their responses to the validated Stress/Urge Incontinence Questionnaire.

Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapse.

Objective: To compare tissue markers of collagen metabolism in the uterosacral ligaments with those in vaginal tissue in women with uterine prolapse.

Design: Prospective observational experimental study.

Setting: A tertiary urogynaecology unit.

Validation of a two-item quantitative questionnaire for the triage of women with urinary incontinence.

Objective: To evaluate the reproducibility, construct validity, and preferences for the 2-item Stress/Urge Incontinence Questionnaire.

Methods: The questionnaire asks a patient to recall the number of stress urinary incontinence and urge urinary incontinence episodes she experienced during the preceding week. The 4-week prospective study included 3 office visits and enrolled women with stress, urge, or mixed urinary incontinence symptoms.