An fMRI Study of Adult Brain Cortical Activation Following Intensive Learning.

Functional imaging techniques, fMRI in particular, has given the possibility to investigate non-invasively the cognitive processes in healthy populations and different disorders concerning neuro-psychiatry, thus unfolding the concepts guiding diagnosis and patient management. Different brain structures seem to support different types of cognitive functions in particular learning and memory thus the neurobiological explanation of the retrieval of information is associated with knowledge of brain plasticity, memory circuits, synaptic neurotransmission and the modulation of glial cells. Consistent with fMRI investigations of memory systems we tested the dependability of a memory paradigm using heterogeneous memory stimuli in order to find the neurobiological basis that correlates with memory task performance.

A Review of Neuroimaging Studies on Working Memory Paradigms in Patients with Bipolar Disorder.

New brain technologies including neuroimaging studies are powerful means for providing new insights into clinical and cognitive neuroscience. Bipolar disorder is a severe chronic phasic mental disease characterized by various cognitive dysfunctions. Working memory is one prominent domain of cognitive impairment in bipolar disorder.