PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.

Background And Aims: Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin resistance, and therefore predisposes to type 2 diabetes and cardiovascular diseases. Lipid deposition in the liver seems to be critical in the pathogenesis of NAFLD. A common genetic variant, the patatin-like phospholipase domain-containing protein 3 (PNPLA3) has been associated with NAFLD.

The association between retinol-binding protein 4 and prediabetes in obese patients with nonalcoholic fatty liver disease.

Context: Retinol-binding protein 4 RBP4) is associated with visceral fat and insulin resistance (IR) in obesity, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), but some of these data remain controversial.

Objective: This study evaluated the relationship between serum RBP4 levels and prediabetes in obese patients with NAFLD.

Methods: A total of 79 obese NAFLD patients without ( = 41) and with prediabetes ( = 38) were included.