Effects of co-exposure to atrazine and ethanol on the oxidative damage of kidney and liver in Wistar rats.

Both ethanol (EtoH) and atrazine (ATZ) have hepatic and nephro-toxic effects in rats. In the present study, the toxicity of EtoH (5 g kg) on the kidney and liver in the absence or in the presence of different doses of ATZ (50, 100, 300 mg kg) was evaluated after 21 days in rats. Results showed that the mixture effects on catalase and superoxide dismutase activities were more severe in both tissues compared to EtoH alone, especially as the dose of ATZ was increased.