Publications by authors named "Ase H Morsund"
Amyotrophic lateral sclerosis caused by the expansion in Norway - prevalence, ancestry, clinical characteristics and sociodemographic status.
Amyotroph Lateral Scler Frontotemporal Degener
September 2024
Objective: The most common genetic cause of amyotrophic lateral sclerosis (ALS) is the expansion. A high incidence of this expansion has been detected in Sweden and Finland. This Norwegian population-based study aimed to identify the prevalence, geographic distribution, ancestry, and relatedness of ALS patients with a expansion (C9).
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- Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that impacts motor neurons, with genetic variants identified in 40-70% of familial and around 5% of sporadic cases in Europe; however, this has not been extensively researched in Norway.
- The study involved analyzing blood samples and clinical data from 279 ALS patients across Norway, revealing that 11.5% had a familial history of ALS and 11.1% had identifiable genetic causes, predominantly the C9orf72 expansion and variants of SOD1 and TBK1.
- Findings emphasize the importance of understanding genetic factors in both familial and sporadic ALS cases to guide potential personalized medicine approaches, as focusing solely on familial cases overlooks a significant portion
Factors influencing employment after minor stroke and NSTEMI.
J Stroke Cerebrovasc Dis
September 2020
Aim: To study the effect of cognitive function, fatigue and emotional symptoms on employment after a minor ischemic stroke compared to non-ST-elevation myocardial infarction (NSTEMI).
Material And Methods: We included 217 patients with minor ischemic stroke and 133 NSTEMI patients employed at baseline aged 18-70 years. Minor stroke was defined as modified Rankin scale (mRS) 0-2 at day seven or at discharge if before.
Objectives: To study the development of cognitive and emotional symptoms between 3 and 12 months after a minor stroke.
Material And Methods: We included patients from stroke units at hospitals in the Central Norway Health Authority and from Haukeland University Hospital. We administered a selection of cognitive tests, and the patients completed a questionnaire 3 and 12 months post-stroke.
Aim: To study the prevalence of cognitive and emotional impairment following a minor ischemic stroke compared to an age-matched group with non-ST-elevation myocardial infarction (NSTEMI).
Methods: We included patients aged 18-70 years with a minor ischemic stroke defined as modified Rankin Scale (mRS) 0-2 at day 7 or at discharge if before and age-matched NSTEMI patients with the same functional mRS. We applied a selection of cognitive tests and the patients completed a questionnaire comprising of Hospital Anxiety and Depression scale (HADS) and Fatigue Severity Scale (FSS) at follow-up 12 months after the vascular event.
Background: Transient ischemic attack (TIA) is a risk factor of stroke. Modern treatment regimens and changing risk factors in the population justify new estimates of stroke risk after TIA, and evaluation of the recommended ABCD stroke risk score.
Methods: From October, 2012, to July, 2014, we performed a prospective, multicenter study in Central Norway, enrolling patients with a TIA within the previous 2 weeks.
Background: The aim of this study was to assess the feasibility, clinical effect and safety of intravenous thrombolysis with tissue plasminogen activator in patients with acute ischaemic stroke treated in an acute stroke unit.
Methods: All patients admitted within 3 h after an acute ischaemic stroke were considered for thrombolysis. Twenty-four patients were treated.