Publications by authors named "Asdis Hjalmsdottir"
Article Synopsis
- Vaccines typically rely on T lymphocytes for B-cell activity and memory, but the study shows that specific peptide and adjuvant combinations can induce antibody responses without T-cell help.
- Mice immunized with liposomes carrying 15mer peptides and monophosphoryl lipid A (MPLA) exhibited a rapid IgG class switch and long-lasting antibody responses, highlighting a novel mechanism of T-cell independent antibody production.
- This T-cell independent response could be beneficial in situations where T-cell immunity is impaired or when immediate antibody protection is required, indicating potential for new vaccine strategies.
One of the greatest pharmaceutical challenges in vaccinology is the delivery of antigens to the cytosol of antigen-presenting cells (APCs) in order to allow for the stimulation of major histocompatibility complex (MHC) class I-restricted CD8(+) T-cell responses, which may act on intracellular infections or cancer. Recently, we described a novel method for cytotoxic T-lymphocyte (CTL) vaccination by combining antigens with a photosensitizer and light for cytosolic antigen delivery. The goal of the current project was to test this immunization method with particle-based formulations.
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