Granular type I corneal dystrophy in a large consanguineous Tunisian family with homozygous p.R124S mutation in the gene.

: We report the clinical features and the mutational analysis in a large Tunisian family with granular corneal dystrophy type I (GCD1). : Thirty-three members of the Tunisian family underwent a complete ophthalmologic examination. DNA extraction and direct Sanger sequencing of the exons 4 and 12 of transforming growth factor β Induced (TGFBI) gene was performed for 42 members.