Alterations in the miR-145/143 cluster expression in multiple sclerosis patients and their correlation with clinical variables.

Multiple sclerosis (MS) is a complex, neurodegenerative and autoimmune disease with a multifactorial etiology. Epigenetic changes can influence the onset and development of the disease, and miRNAs, small RNAs that play a key role in post-transcriptional gene regulation, act as important modulators of the inflammatory process and the central nervous system´s response. The objective of this work is to compare and identify the expression of the miR-143/145 cluster, namely miR-143-5p and miR-145-5p.