Publications by authors named "Asami Kato"

Article Synopsis
  • - Clear cell carcinoma (CCC) of the diaphragm is a rare cancer, often linked to malignant changes in extraperitoneal endometriosis, and it is commonly associated with Lynch syndrome (LS), which increases women’s risk for endometrial and ovarian cancers.
  • - The study highlights a case of a 51-year-old woman with a history of atypical endometrial hyperplasia and endometriosis, who was found to have a diaphragmatic tumor that was diagnosed as CCC after surgical removal and pathological analysis.
  • - Genetic testing confirmed the presence of a pathogenic variant in a DNA mismatch repair gene, establishing a diagnosis of Lynch syndrome; this case emphasizes the importance of monitoring women with LS and endometriosis for potential malignancies
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Article Synopsis
  • - Polyadenosine 5'-diphosphoribose polymerase inhibitors (PARP-Is) are effective for treating newly diagnosed epithelial ovarian cancer (EOC), but their impact on recurrent cases is still unclear.
  • - A case study involved a 69-year-old woman with BRCA1 mutated EOC who relapsed shortly after PARP-I treatment, but subsequent therapy with nedaplatin and niraparib led to a complete response.
  • - The findings suggest that even if there's short-term progression on PARP-I, combining different treatment strategies can still yield positive outcomes in managing recurrent EOC.
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  • A 41-year-old woman experienced abdominal pain and was diagnosed with a large ovarian tumor, which turned out to be a rare borderline tumor from an extragonadal giant endometrial cyst.
  • Imaging revealed a 27 cm × 9 cm cystic tumor, which was surgically removed laparoscopically without involvement of the ovaries.
  • Post-surgery analysis showed it was an endometrioid borderline tumor linked to endometriosis, and a staging laparotomy confirmed no remaining tumor, highlighting the rarity of this case.
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Article Synopsis
  • * A study reviewed cases of PGHA treatment to evaluate management strategies and determine key clinical indicators that guide treatment decisions.
  • * Findings revealed that higher shock index and lower platelet and fibrinogen levels were linked to arterial embolization treatment, suggesting that specific clinical markers can aid in choosing the appropriate management approach for PGHA.
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We describe an extremely rare case of an unusually presented ovarian fibroma adherent to the sigmoid colon originating from an autoamputated ovary. A 64-year-old woman was referred to our hospital with an abnormal shadow that was approximately 4 cm in diameter in the pelvic cavity detected on abdominal X-ray imaging. Computed tomography demonstrated an irregularly shaped tumor with calcification in the pelvic cavity.

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Dendritic spine is a small membranous protrusion from a neuron's dendrite that typically receives input from an axon terminal at the synapse. Memories are stored in synapses which consist of spines and presynapses. Rapid modulations of dendritic spines induced by hippocampal sex steroids, including dihydrotestosterone (DHT), testosterone (T), and estradiol (E2), are essential for synaptic plasticity.

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A previously healthy 37-year-old Canadian man living in Japan visited a hospital in Thailand while traveling because of edematous legs, purpura, arthralgia, bloody stool, and fever after an insect bite. Henoch-Schönlein purpura (HSP) was suspected. His creatinine level was 5.

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Eyes are supplied O through the cornea and vessels of the retina and iris, which are tissues characterized by aerobic metabolism. Meanwhile, there are no reports on the association between iris sphincter contraction and aerobic metabolism. In this paper, we studied the aforementioned association.

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The corticosterone (CORT) level changes along the circadian rhythm. Hippocampus is sensitive to CORT, since glucocorticoid receptors are highly expressed. In rat hippocampus fixed in a living state every 3 h, we found that the dendritic spine density of CA1 pyramidal neurons increased upon waking (within 3 h), as compared with the spine density in the sleep state.

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We investigated age-induced changes in mRNA expression profiles of sex-steroidogenic enzymes and sex-steroid receptors in 3-, 12-, and 24-month-old male rat brain subregions [cerebral cortex (CC), hypothalamus (Hy) and cerebellum (CL)]. In many cases, the expression levels of mRNA decreased with age for androgen synthesis enzyme systems, including Cyp17a1, Hsd17b and Srd5a in the CC and CL, but not in the Hy. Estradiol synthase Cyp19a1 did not show age-induced decline in the Hy, and nearly no expression of Cyp19a1 was observed in the CC and CL over 3-24 m.

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A previously healthy 46-year-old black man visited the other hospital because of fever, appetite loss and nausea. Renal dysfunction, liver injury, and a highly markedly elevated LDH level were found. Abdominal CT demonstrated enlarged liver, spleen, kidney and lymph nodes.

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Synaptic plasticity of the female hippocampus may cyclically fluctuate across the estrous cycle. The spine density fluctuation had been explained by fluctuation of plasma estradiol (E2) and progesterone (PROG), with the assumption that these steroids penetrate into the hippocampus. Recently, however, we demonstrated that male hippocampal levels of sex steroids are much higher than those in plasma, suggesting a weak contribution of plasma steroids to the spine density.

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Tumor dissemination and invasive behavior are associated with a majority of cancer-related mortality cases. Loss of E-cadherin, which is caused by several tumor-promoting factors, is associated with metastasis and poor prognosis in many neoplasms. In this study, we aimed to identify small molecule compounds that restore the expression of E-cadherin, because these molecules are most likely to suppress tumor malignancy by restoring E-cadherin function and/or by inhibiting signals that suppress E-cadherin expression.

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