Publications by authors named "Asako Tsuda"
Article Synopsis
- WT1 gene is often overexpressed in leukemia and solid tumors, contributing to cancer development (leukemogenesis and tumorigenesis).
- Short hairpin RNA targeting WT1 exon 5 (shWTE5) effectively induces apoptosis in various cancer cell lines and enhances the effects of chemotherapy drugs like doxorubicin and etoposide.
- shWTE5 also alters the balance of pro- and anti-apoptotic proteins, suggesting that it could be a strong anti-cancer agent for treating solid tumors by suppressing certain WT1 isoforms.
The wild-type Wilms' tumor gene WT1 is overexpressed in human primary leukemia and in a wide variety of solid cancers. All of the four WT1 isoforms are expressed in primary cancers and each is considered to have a different function. However, the functions of each of the WT1 isoforms in cancer cells remain unclear.
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