[Indices of Visual Improvement after Conservative Treatment for Branch Retinal Vein Occlusion with Macular Edema].

Purpose: To identify indices of visual improvement after conservative treatment for branch retinal vein occlusion (BRVO) with macular edema. Methods: We retrospectively reviewed the charts of 33 eyes of 33 patients with BRVO with macular edema. Inclusion criteria were 1) onset within 4 months, 2) decimal visual acuity of 0.

Macular degeneration in a Japanese patient with aceruloplasminemia.

Purpose: To characterize the clinical features of a Japanese patient with macular degeneration in aceruloplasminemia.

Methods: The clinical features were evaluated by visual acuity measurements, fluorescein angiography, electroretinography, and kinetic visual field testing.

Results: We observed a Japanese patient with macular degeneration in aceruloplasminemia.

Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa.

Purpose: To determine whether mutations in the MERTK gene are present in Japanese patients with autosomal recessive retinitis pigmentosa (arRP).

Methods: The coding sequence of all 19 exons and the adjacent flanking intron sequences of the MERTK gene were directly sequenced in 96 unrelated Japanese patients with arRP.

Results: Seventeen sequence variants were found; six missense changes, three isocoding changes, and eight intron changes were also observed.

Screening for mutations in the IMPDH1 gene in Japanese patients with autosomal dominant retinitis pigmentosa.

Purpose: To determine the presence and frequency of mutations in the IMPDH1 gene in Japanese patients with autosomal dominant retinitis pigmentosa (ADRP), and to characterize the clinical characteristics of patients with the Lys238Arg mutation in the IMPDH1 gene.

Design: Case reports and results of DNA analysis.

Methods: All 14 coding exons of the IMPDH1 gene were directly sequenced in 96 unrelated patients with ADRP.

Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy.

Purpose: To describe the clinical and genetic characteristics of six Japanese families with Bietti's crystalline corneoretinal dystrophy (BCD).

Design: Case reports and results of DNA analysis.

Methods: Mutation screening was performed on six unrelated patients with BCD by direct sequencing.