Publications by authors named "Asako Mizobuchi"
Aim: Familial hypercholesterolemia (FH) is an underdiagnosed autosomal dominant genetic disorder characterized by high levels of plasma low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the genetic identification of FH in children with high LDL-C levels who are identified in a universal pediatric FH screening in Kagawa, Japan.
Method: In 2018 and 2019, 15,665 children aged 9 or 10 years underwent the universal lipid screening as part of the annual health checkups for the prevention of lifestyle-related diseases in the Kagawa prefecture.
Background: The impairment of short-term heart rate regulation in patients with heart failure with preserved ejection fraction (HFpEF) can cause acute hemodynamic collapse. Detrended fluctuation analysis (DFA) is a useful tool for the diagnosis of heart diseases and the prediction of mortality. In DFA, the short-term scaling exponent α is decreased in heart failure.
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- The coronary artery calcium data and reporting system (CAC-DRS) offers a new method for assessing coronary artery calcium severity, particularly relevant for lung cancer patients who have a heightened risk of cardiovascular disease (CVD).
- A study involving 309 lung cancer patients showed that higher CAC-DRS scores correlate with an increased risk of major adverse cardiac events (MACEs) and all-cause death, even after adjusting for other factors.
- The findings suggest that lung cancer survivors with higher CAC-DRS scores may require more intensive management of cardiovascular risk factors to improve their overall health outcomes.