Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation.

Neuromodulation therapy comprises a range of non-destructive and adjustable methods for modulating neural activity using electrical stimulations, chemical agents, or mechanical interventions. Here, we discuss how electrophysiological brain recording and imaging at multiple scales, from cells to large-scale brain networks, contribute to defining the target location and stimulation parameters of neuromodulation, with an emphasis on deep brain stimulation (DBS).

Modeling and optimization of surface modification process of ultrafiltration membranes by guanidine-based deep eutectic solvent.

Low performance and the high fouling tendency of Polyetherimide (PEI) membranes prevent their widespread commercial utility. In this study, we utilized a deep eutectic solvent (DES) as a versatile agent for surface modification of the PEI membrane using a simple and sustainable method. To attain an efficient PEI membrane, modeling and optimization of the modification condition were conducted via response surface methodology (RSM).

Recent advances in bioactive materials: Future perspectives and opportunities in oral cancer biosensing.

Bioactive materials and biosensing technologies are emerging as pivotal tools in the early detection and management of oral cancer, a disease characterized by high morbidity and mortality rates. Recent advancements in nanotechnology have facilitated the development of innovative biosensors that utilize bioactive materials for non-invasive diagnostics, particularly through salivary analysis. These biosensors, including electrochemical, optical, and molecular types, target specific biomarkers such as DNA, RNA, and proteins associated with oral cancer.

Dairy consumption and premature coronary artery disease onset: Iran premature coronary artery disease (IPAD) study insights.

Evidence has argued about the association between dairy intake and premature coronary artery disease (PCAD) development aimed to be discussed in this study. This case-control study was conducted on 813 individuals with PCAD and 471 healthy controls. The dairy intake of participants was assessed by a validated semi-quantitative food frequency questionnaire.

A secure and efficient blockchain enabled federated Q-learning model for vehicular Ad-hoc networks.

Vehicular Ad-hoc Networks (VANETs) are growing into more desirable targets for malicious individuals due to the quick rise in the number of automated vehicles around the roadside. Secure data transfer is necessary for VANETs to preserve the integrity of the entire network. Federated learning (FL) is often suggested as a safe technique for exchanging data among VANETs, however, its capacity to protect private information is constrained.

Ultra-processed food intake in relation to metabolic health status in Iranian adolescents with overweight and obesity.

Background: Many studies have explored the association between food intake and metabolic health. However, research on the association of consuming ultra-processed foods (UPFs) and metabolic health in children and adolescents remains unclear. The objective of our study was to investigate the relation between UPFs consumption and metabolic health status in Iranian adolescents with overweight/obesity.

Electrochemical biosensors for depression: Diagnosis and therapeutic monitoring.

Electrochemical biosensors have revolutionized the detection of biomarkers related to depression and the quantification of antidepressant drugs. These biosensors leverage nanomaterials and advanced assay designs to achieve high sensitivity and selectivity for clinically relevant analytes. Key neurotransmitters implicated in depression, such as serotonin, dopamine, and glutamate, can be accurately measured via biosensors, providing insights into the effects of antidepressant treatments on neurotransmission.

Association between , , , and gene polymorphisms and breast cancer risk.

Aim: In this study, we examined the polymorphisms of (rs13252298, rs1456315), (rs4848320) (rs7158663), (rs7853346) genes in BC patients and compared it with healthy individuals in an Iranian population.

Method: The assessment of genetic polymorphisms was conducted using PCR - RFLP and PCR-Tetra ARMS methods.

Results & Conclusion: The results showed that Codominant, Dominant and G allele of rs13252298 polymorphism and Dominant of rs1456315 polymorphism are correlated with increased risk of BC.

Acceptance-Hesitancy of COVID-19 Vaccination and Factors Affecting It in Adults: Systematic Review Study.

Background: Despite the advent of vaccines against COVID-19, there is considerable variation in the acceptance and hesitancy towards the vaccination program across different countries. The objective of this study was to ascertain the prevalence of hesitancy and acceptance regarding the use of the vaccine against the novel coronavirus, also known as COVID-19, and to identify the factors that influence these attitudes.

Materials And Methods: All the cross-sectional studies were retrieved from the PubMed databases, the Web of Science ISI, Scopus, and the Cochrane Library.

The relationship between the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and metabolic health status in adolescents with overweight and obesity: results from a cross-sectional study in Iran.

Few studies investigated the association between Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and metabolic health status, particularly among adolescents. The present study was designed to investigate the association of MIND diet with metabolic health status in Iranian adolescents with overweight/obesity. This cross-sectional study was done among 203 adolescents with overweight/obesity (12-18 years) in Isfahan, Iran.

The rs2275738 variant of the adiponectin receptor 1 gene is associated with biopsy-proven nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) is a significant health issue worldwide. This study investigated the effect of the adiponectin receptor 1 gene () polymorphism on susceptibility to NAFLD. Data from 330 participants, including 165 biopsy-proven NAFLD patients and 165 healthy controls, were collected.

Electrochemical biosensors in early detection of Parkinson disease.

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting the motor system, with symptoms including tremors, rigidity, bradykinesia, and postural instability. Affecting over six million people globally, PD's pathophysiology is marked by the loss of dopaminergic neurons in the substantia nigra. Early diagnosis is crucial for effective management, yet current methods are limited by low sensitivity, high cost, and the need for advanced equipment.

Unraveling the genetic basis of oil quality in olives: a comparative transcriptome analysis.

Introduction: The balanced fatty acid profile of olive oil not only enhances its stability but also contributes to its positive effects on health, making it a valuable dietary choice. Olive oil's high content of unsaturated fatty acids and low content of saturated fatty acids contribute to its beneficial effects on cardiovascular diseases and cancer. The quantities of these fatty acids in olive oil may fluctuate due to various factors, with genotype being a crucial determinant of the oil's quality.

Machine learning-aided microRNA discovery for olive oil quality.

MicroRNAs (miRNAs) are key regulators of gene expression in plants, influencing various biological processes such as oil quality and seed development. Although, our knowledge about miRNAs in olive (Olea europaea L.) is progressing, with several miRNAs being identified in previous studies, but most of these reported miRNAs have been predicted without the aid of a reference genome, primarily due to limited genome accessibility at the time.

Evans syndrome in conjunction with rheumatoid arthritis and SLE: A unique case of autoimmune intersection.

Evans syndrome is a rare autoimmune disorder characterized by autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP), often linked with systemic lupus erythematosus (SLE). We present a case of a 25-year-old female with a history of rheumatoid arthritis (RA) who presented with new SLE symptoms, including left-sided weakness, pallor, and a photosensitive rash. Laboratory tests confirmed Evans syndrome, and MRI showed a cerebral infarction.

Effects of probiotics supplementation on glycemic profile in adults with type 2 diabetes mellitus: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

Background: Disturbed glycemia and the resulting type 2 diabetes (T2D) are significant health concerns. Various approaches have been examined to improve glycemic control in patients with T2D. Modification of gut microbiome via administering probiotics has been extensively studied.

A Comparative Review of Tocosomes, Liposomes, and Nanoliposomes as Potent and Novel Nanonutraceutical Delivery Systems for Health and Biomedical Applications.

Contemporary nutraceutical and biomedical sectors are witnessing fast progress in efficient product development due to the advancements in nanoscience and encapsulation technology. Nutraceuticals are generally defined as food substances, or a section thereof, that provide us with health benefits such as disease prevention and therapy. Nutraceutical and biomedical compounds as well as food supplements are a natural approach for attaining therapeutic outcomes with negligible or ideally no adverse effects.

Impacts of post-operation loading and fixation implant on the healing process of fractured tibia.

Healing of tibia demonstrates a complex mechanobiological process as it is stimulated by the major factor of strains applied by body weight. The effect of screw heads and bodies as well as their pressure distribution is often overlooked. Hence, effective mechanical conditions of the healing process of tibia can be categorized into the material of the plate and screws, post-operation loadings, and screw type and pressure.

Standing Long Jump Performance Is Enhanced When Using an External as Well as Holistic Focus of Attention: A Kinematic Study.

Standing long jump is known as one of the important skills in the success of athletes in most sports. In addition, one of the most effective factors that can affect standing long jump distance and kinematics is the focus of attention used by the athlete. Therefore, the aim of the present study was to compare the effect of internal, external, and holistic focus of attention instructions on standing long jump performance and kinematics.

Finite Element Assessment of a Novel Patient-Specific Mandibular Implant for Severely Atrophic Ridge.

Dental reconstruction for patients diagnosed with severe mandibular bone atrophy using common dental implants is a challenging process. In such cases, surgeons may encounter challenges such as insufficient available bone, soft tissue, damage to the inferior alveolar nerve, and even the risk of bone fracture. In this study, a new design concept of mandibular patient-specific implants for severely atrophic ridges followed by finite element evaluation was presented to investigate the mechanical functionality of the concept.

Engineering the Crystalline Architecture for Enhanced Properties in Fast-Rate Processing of Poly(ether ether ketone) (PEEK) Nanocomposites.

Rapid cooling in fast-rate manufacturing processes such as additive manufacturing and stamp forming limits the development of crystallinity in semicrystalline polymer nanocomposites and, therefore, potential improvements in the mechanical performance. While the nucleation, chain mobility, and crystallization time from rapid cooling are known competing mechanisms in crystallization, herein we elucidate that the crystalline morphology and architecture also play a key role in tuning the mechanical performance. We explore how modifying the spherulite morphology via a cellulose nanocrystal (CNC) and graphene nanoplatelet (GNP) hybrid system in their pristine form can improve or preserve the mechanical properties of poly(ether ether ketone) (PEEK) nanocomposites under two extreme cooling rates (fast -460 °C/min and slow -0.

The rs1862513 promoter variant of resistin gene influences susceptibility to nonalcoholic fatty liver disease.

Objectives: Nonalcoholic fatty liver disease is the term used for a range of conditions in which fat builds up in the liver and exceeds 5% of hepatocytes without inordinate alcohol intake or other causes of lipid accumulation. Regarding the fact that insulin resistance and obesity play key roles in the pathogenesis of nonalcoholic fatty liver disease, as well as the connection between resistin and these metabolic diseases, the association between nonalcoholic fatty liver disease and a resistin gene (RETN) polymorphism was examined.

Methods: In this genetic case-control association study, 150 biopsy-proven nonalcoholic fatty liver disease patients and 154 controls were enrolled and genotyped for the RETN rs1862513 (-420C>G) gene polymorphism using PCR-RFLP method.