Publications by authors named "Asa H Everhov"
Background And Aim: Only few studies have examined the socioeconomic consequences of being diagnosed with inflammatory bowel disease (IBD) in childhood or youth. Disease severity has been linked to lower earnings, but little attention has been paid to comorbid mental health conditions. The aim is to examine labour market participation (LMP) and income in patients with IBD-onset in childhood or youth and examine how disease severity and mental health conditions affects LMP.
View Article and Find Full Text PDFIntroduction: Despite its increasing prevalence, the economic impact of eosinophilic esophagitis (EoE) is understudied.
Methods: We estimated the societal economic burden of EoE by using real-world data from Swedish health registers.
Results: Patients with EoE had 45% higher societal cost ($6,290 vs $4,349) compared with the general population, primarily driven by increased healthcare costs ($2,414 vs $1,022), which accounted for 72% of the excess societal cost in EoE.
Background: The situation for patients with ostomy can be challenging, probably more in a resource-constrained environment. Our objective was to evaluate quality of life (QoL) (using EQ5D-5L) and stoma-specific QoL (using Stoma QoL) in a high- and low-income setting.
Methods: In this cross-sectional study from the Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, and South General Hospital (SGH), Stockholm, patients with a permanent or temporary ostomy at TASH (EthioPerm), (EthioTemp), and patients with ostomy at SGH (SweSto) were included in October 2022-January 2023.
Background: There are conflicting data on the risk of acute coronary syndrome (ACS) in patients with inflammatory bowel disease (IBD). Only a few previous reports include patients diagnosed during the last decade.
Aim: To assess and compare the risk of ACS between patients with IBD and the general population.
Background: Rectal cancer is a common cancer worldwide. Surgery for rectal cancer with low anterior resection often includes the formation of a temporary protective loop ileostomy. The temporary ostomy is later reversed in a separate operation.
View Article and Find Full Text PDFIncreasing healthcare costs in inflammatory bowel disease 2007-2020 in Sweden.
Aliment Pharmacol Ther
October 2023
Background: Inflammatory bowel disease has been linked to increasing healthcare costs, but longitudinal data on other societal costs are scarce.
Aim: To assess costs, including productivity losses, in patients with prevalent Crohn's disease (CD) or ulcerative colitis (UC) in Sweden between 2007 and 2020.
Methods: We linked data from national registers on all patients with CD or UC and a matched (sex, birthyear, healthcare region and education) reference population.
Article Synopsis
- There is limited information on the positioning of biologics in treating Crohn's disease (CD), specifically comparing ustekinumab and anti-TNF agents following first-line anti-TNF treatment.
- A study using Swedish nationwide registers analyzed 312 CD patients who switched to either ustekinumab or a second-line anti-TNF, measuring outcomes like drug survival, hospital admissions, and surgery rates over three years.
- The results showed no significant differences in drug survival or safety between ustekinumab and anti-TNF, suggesting both treatments are similarly effective for CD patients previously treated with anti-TNF.
Editorial: colorectal cancer in elderly-onset IBD-what is the risk? Authors' reply.
Aliment Pharmacol Ther
November 2022
Article Synopsis
- A study analyzed data from Danish and Swedish national registers to identify 6,937 childhood-onset Crohn's Disease (CD) and 8,514 childhood-onset Ulcerative Colitis (UC) patients, tracking their health outcomes from 1969 to 2017.
- Among patients, the incidence of colorectal cancer (CRC) was significantly higher in those with CD (0.36%) and UC (1.33%) compared to matched reference individuals (0.06% and 0.05% respectively).
- The study found that the risk of CRC was particularly high for patients with severe forms of these diseases, indicating that younger age at diagnosis could be an important factor for monitoring CRC risk in these patients.
Background: IBD with onset during childhood seems to represent a severe disease phenotype with increased morbidity. We have previously demonstrated that children with IBD have significantly lower final grades in compulsory school compared to healthy peers.
Aim: To evaluate the association of childhood-onset IBD with a later professional career and subsequent earnings METHODS: We identified 5404 individuals diagnosed with childhood-onset (<18 years) IBD between 1990 and 2014 (2818 with ulcerative colitis and 2328 with Crohn's disease) in the Swedish National Patient Register.
Background: Previous research indicates that the increased relative risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) is limited to young-onset IBD.
Aim: To estimate risks of incident CRC and death from CRC in elderly-onset IBD METHODS: Patients diagnosed with IBD at age ≥ 60 years between 1969 and 2017 were identified using Danish and Swedish National Patient Registers and histopathology data. We linked data to Cancer and Causes of Death Registers and used Cox regression to estimate hazard ratios (HRs) for CRC diagnosis and death compared to matched (by sex, age, and region) IBD-free individuals.
Importance: The COVID-19 pandemic has had a large impact on health care systems, not least the treatment of malignant diseases, including colorectal cancer.
Objective: To investigate the treatment of colorectal cancer and short-term outcomes during the first wave of the COVID-19 pandemic, compared with the year before.
Design, Setting, And Participants: This register-based cohort study used information from the Swedish Colorectal Cancer Registry during the years 2020 and 2019.
Aim: The COVID-19 pandemic has reduced the capacity to diagnose and treat cancer worldwide due to the prioritization of COVID-19 treatment. The aim of this study was to investigate treatment and outcomes of colon cancer in Sweden before and during the COVID-19 pandemic.
Methods: In an observational study, using the Swedish Colorectal Cancer Registry, we included (i) all Swedish patients diagnosed with colon cancer, and (ii) all patients undergoing surgery for colon cancer, in 2016-2020.
Article Synopsis
- * Data was collected from a nationwide cohort in Sweden, tracking Crohn's disease patients who started TNFi treatment from 2006 to 2017, and measuring bowel surgery incidents a year after treatment began.
- * The results revealed that patients who continued TNFi treatment for 12 months or more had a significantly lower surgery rate compared to those who used it for less than 12 months, indicating the importance of sustained TNFi therapy in managing Crohn's disease
Background: Critically ill COVID-19 patients have a high reported incidence of thromboembolic complications and the optimal dose of thromboprophylaxis is not yet determined. The aim of this study was to investigate if 90-day mortality differed between patients treated with intermediate- or high-dose thromboprophylaxis.
Method: In this retrospective study, all critically ill COVID-19 patients admitted to intensive care from March 6th until July 15th, 2020, were eligible.
Background: Restorative surgery after colectomy due to ulcerative colitis (UC) may be performed simultaneously with colectomy (primary) or as a staged procedure. Risk factors for failure after restorative surgery are not fully explored. This study aimed to compare the risk of failure after primary and staged reconstruction.
View Article and Find Full Text PDFRobot-assisted ventral hernia repair, when performed correctly, may reduce the risk for pain and discomfort in the postoperative period thus enabling shorter hospital stay. The aim of the present study was to evaluate postoperative pain following robot-assisted laparoscopic repair. The approach was selected after an intraoperative decision to complete the repair as: (1).
View Article and Find Full Text PDFArticle Synopsis
- A study analyzed the incidence of stoma formation in Crohn's disease patients from 2003 to 2014 and followed them until 2019, linking national health registers to gather data.
- Out of 18,815 patients, 3.5% formed a stoma, primarily during ileocolic resection, with a 5-year cumulative incidence remaining stable across different periods (2.5%).
- The study found that older patients were more likely to have stomas compared to younger ones, and although anti-TNF treatment has increased, the overall rates of stoma formation did not decrease over the study period.
Work Loss in Patients With Celiac Disease: A Population-based Longitudinal Study.
Clin Gastroenterol Hepatol
May 2022
Background & Aims: Celiac disease (CD) affects around 1% of the population worldwide. Data on work disability in patients with CD remain scarce. We estimated work loss in patients with CD, including its temporal relationship to diagnosis.
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- The study aimed to assess central pulmonary embolism (PE) in Covid-19 patients, examining its relationship with severe lung changes, anticoagulation treatment, and ICU care.
- Out of 1162 Covid-19 patients, 41 (3.5%) were found to have PE, with a significant number (63.4%) having central PE, particularly among ICU patients (82.4%).
- No correlation was found between central PE and either prophylactic anticoagulation or the severity of lung damage caused by Covid-19.
Article Synopsis
- A study was conducted to assess how well biologic treatments for inflammatory bowel disease (IBD) are recorded in Sweden's Prescribed Drug Register (PDR) and National Patient Register (NPR), comparing this data with medical records from 2005 to 2017.
- The analysis involved reviewing records of 1,361 patients and found that 80.1% of treatment episodes were captured in the PDR/NPR, but sensitivity dropped significantly when considering narrower time windows.
- While the registers are reliable for injectable biologics like adalimumab and ustekinumab, they show poor accuracy for infusion drugs like infliximab and vedolizumab, suggesting caution when using these databases and considering additional sources
Background: To avoid a permanent stoma, restorative surgery is performed after the colectomy. Previous studies have shown that less than half of patients with ulcerative colitis undergo restorative surgery.
Objective: The primary aim was to explore the association between socioeconomic status and restorative surgery after colectomy.
Background: Central obesity is associated with surgical difficulties, but few studies explore the relationship with long-term results after colon cancer surgery.
Objective: The purpose of this study was to investigate the association between perirenal fat surface area, a proxy for total visceral fat, and oncologic outcome after intestinal resection for colon cancer.
Design: We investigated the association between perirenal fat surface area (exposure) on recurrence and death (outcome) in patients undergoing surgery with curative intent for colon cancer.
Background And Aims: Patients with inflammatory bowel disease [IBD] are subject to more work disability than the general population. We aimed to estimate the monetary cost of IBD for the individual through assessment of earnings in relation to diagnosis.
Methods: Through linkage of national registers, we identified patients aged 30-55 years at first IBD diagnosis in Sweden in 2002-2011, and same-sex IBD-free siblings.
Background: A substantial proportion of critically ill COVID-19 patients develop thromboembolic complications, but it is unclear whether higher doses of thromboprophylaxis are associated with lower mortality rates. The purpose of the study was to evaluate the association between initial dosing strategy of thromboprophylaxis in critically ill COVID-19 patients and the risk of death, thromboembolism, and bleeding.
Method: In this retrospective study, all critically ill COVID-19 patients admitted to two intensive care units in March and April 2020 were eligible.