Publications by authors named "As Kumar"

Impact of climate change that stems from gaseous emissions require sustainable materials to eliminate sulfur.  This study involves the modification of humic acid with magnetite nanoparticles (Fe₃O₄ NPs) by a microwave-assisted synthesis of an absorbent with reasonable pore volume and diameter for elimination of thiophenic compounds from fuel. The magnetic nano adsorbent designated Fe3O4@HA was characterized using advanced spectroscopic techniques, while their structure and morphology were analyzed through DLS, XPS, XRD, FT-IR, TGA, FESEM-EDX, VSM, and BET-N2 techniques.

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Extracellular vesicles (EVs) are nanoscale, membrane-enclosed structures released by cells into the extracellular milieu. These vesicles encapsulate a diverse array of molecular constituents, including nucleic acids, proteins, and lipids, which provide insights into the physiological or pathological conditions of their parent cells. Despite their potential, the study of EV-derived DNA (EV-DNA) has gathered relatively limited attention.

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Acute coronary syndrome (ACS) encompasses a spectrum of coronary artery diseases, including unstable angina, non-ST segment elevation myocardial infarction, and ST-segment elevation MI. At present, ACS is a major cause of mortality and morbidity in the community. The diagnosis of ACS is of critical importance for guiding appropriate therapeutic strategies, although this can be onerous if the standard presenting manifestations are lacking.

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Lymphatic muscle cells (LMCs) within the wall of collecting lymphatic vessels exhibit tonic and autonomous phasic contractions, which drive active lymph transport to maintain tissue-fluid homeostasis and support immune surveillance. Damage to LMCs disrupts lymphatic function and is related to various diseases. Despite their importance, knowledge of the gene transcriptional signatures in LMCs and how they relate to lymphatic function in normal and disease contexts is largely missing.

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Background: Physical forces exerted by expanding brain tumors - specifically the compressive stresses propagated through solid tissue structures - reduces brain perfusion and neurological function, but heretofore has not been directly measured in patients . Solid stress levels estimated from tumor growth patterns are negatively correlated with neurological performance in patients. We hypothesize that measurements of solid stress can be used to inform clinical management of brain tumors.

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Multipliers are essential components within digital signal processing, arithmetic operations, and various computational tasks, making their design and optimization crucial for improving the efficiency and performance of integrated circuits. Among multiplier architectures, Vedic multipliers stand out due to their inherent efficiency and speed, derived from ancient Indian mathematical principles. This study presents a comprehensive analysis and comparison of 4-bit Vedic multiplier designs utilizing Gate Diffusion Input (GDI), Complementary Metal-Oxide-Semiconductor (CMOS), and Transmission Gate (TG) technologies, utilizing different adder architectures such as Ripple Carry Adder (RCA), and Carry Lookahead Adder (CLA), Carry Skip Adder (CSA).

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Introduction: The study aims to investigate the antifungal efficacy of albedo extract of Punica grantum on candida albicans by evaluating the inhibitory capacity of alcoholic albedo extracts by disc diffusion method and by comparing the antifungal efficacy of alcoholic extract of albedo with clotrimazole and ethanol.

Methods: Using a conventional disc diffusion method, the effectiveness of Punica Granatum albedo extract against Candida albicans was assessed and evaluated depending on the presence or absence of inhibition zones, as well as the average diameter of inhibition zones. Albedo extract of Punica granatum serial dilutions were prepared ranging from 1%, 5%, 10%, 15%, 20% and 25% and its antifungal efficacy was tested against Candida albicans in comparison with clotrimazole and ethanol.

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Optomechanical devices based on sliced silicon photonic crystal nanobeams could have several use cases in future quantum technologies, especially as quantum transducers between different quantum systems. To create the required pure mechanical states at low temperatures, an understanding of photon absorption, thermal relaxation, and the associated photothermal force is crucial. Here, we characterize the strength of the photothermal force in sliced silicon nanobeam resonators.

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  • - Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting 8-13% of women, characterized by multiple cysts in the ovaries and symptoms like insulin resistance, excessive hair growth, and irregular menstrual cycles, influenced by genetics, lifestyle, and environment.
  • - The condition is linked to various serious health risks, including type 2 diabetes, heart disease, and infertility, with its complexities often passed down through generations due to maternal inheritance.
  • - Advances in diagnosis and treatment, from Rotterdam criteria to modern technologies, emphasize the importance of lifestyle changes and medical interventions in managing PCOS and its diverse impacts on women's health from puberty to menopause.
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Existing ecofriendly apprehensions about climate change have directed scientists to discover plant-based vegetable oils for use as fuels, such as straight vegetable oils and their biodiesels, because of their renewability, nontoxic nature, biodegradability, and environmental friendliness. This experimental study intended to reveal the tribological aspects of 90 °C preheated straight vegetable oil (PHSVO90) used in a 7.35 kW, 1000 rpm constant speed indirect injection (IDI) diesel engine and likened to conventional diesel operation by conducting an elongated term durability examination for 512 h as per IS:10000 standards.

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Cancer metastasis is a major contributor to patient morbidity and mortality, yet the factors that determine the organs where cancers can metastasize are incompletely understood. In this study, we quantify the absolute levels of over 100 nutrients available across multiple tissues in mice and investigate how this relates to the ability of breast cancer cells to grow in different organs. We engineered breast cancer cells with broad metastatic potential to be auxotrophic for specific nutrients and assessed their ability to colonize different organs.

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Introduction Laparoscopic surgery is now the gold standard for many common procedures; however, there has been a lack of emphasis on laparoscopic training at the junior level. Simulation is an effective form of training in surgery, but surgical simulation models and courses can be expensive and inaccessible to medical students and foundation doctors. With procedures becoming more minimally invasive, it is key that we train laparoscopic skills at an earlier stage; and to do so, we need to remove the barriers of cost and accessibility.

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  • This study presents a method for creating a 3D nanocomposite of BiOI, ZnO, and carbon nanofibers on a nickel foam substrate through a hydrothermal process.
  • The resulting material showed impressive specific capacitance of 1073 F/g at a current density of 1 A/g and maintained 88.6% of its original capacity after 5000 charge-discharge cycles in a potassium hydroxide solution.
  • These results underscore the potential of 3D nanomaterials as effective electrode materials for advanced supercapacitor applications due to their superior energy storage characteristics.
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  • Management of essential hypertension (HTN) is challenging, with less than 10% of cases controlled according to the latest guidelines from the ACC and ISH.
  • Recent updates, including the ESH 2023 guidelines, highlight the evolving role of beta-blockers, particularly in the context of specific Indian health traits related to cardiovascular disease.
  • An expert panel reached a consensus that beta-blockers, especially nebivolol, are effective first-line treatments for HTN, especially in young patients and those with high resting heart rates.
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Ovine herpesvirus-2 (OvHV-2) is the causative agent of malignant catarrhal fever (MCF), a serious and often fatal disease that affects cattle and other ruminants. This study aimed to investigate the molecular epidemiology and genetic diversity of OvHV-2 strains circulating in sheep and cattle populations in the Jammu and Kashmir region of India. Screening of 150 sheep and 57 cattle blood samples revealed the presence of the OvHV-2 polymerase (pol) gene in 8.

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  • The Transplant Games in Kochi, India created a platform for organ donors and recipients to participate in sports, promoting positivity around organ donation and demonstrating that transplant recipients can lead vibrant lives.
  • A survey was conducted with 150 participants to assess the impact of sports engagement on donors and recipients, receiving a 52% response rate, with demographics showing a predominance of male participants and an average age of 45.
  • Self-motivation was the main reason for engaging in sports, with bowling being the most popular activity, and donors tended to become active in sports earlier than recipients.
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In cases of brain tumors, some brain cells experience abnormal and rapid growth, leading to the development of tumors. Brain tumors represent a significant source of illness affecting the brain. Magnetic Resonance Imaging (MRI) stands as a well-established and coherent diagnostic method for brain cancer detection.

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  • Cancer pain significantly affects the quality of life, with up to 70% prevalence in advanced stages, and is managed using the WHO pain ladder that incorporates NSAIDs, opioids, and adjuvant medications.
  • A case study of a patient with metastatic colon cancer experiencing severe pain and immobility due to epidural metastasis illustrates the limitations of traditional pain management strategies.
  • The patient benefited from spinal cord stimulation, achieving over 80% pain relief and functional recovery, highlighting the need for alternative pain management solutions as the medical community shifts away from opioid reliance.
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  • Prostate cancer is a major health issue for males, being the second most diagnosed cancer globally, while radiation therapy, a common treatment, has several adverse effects, leading to interest in proton beam therapy for its precision and reduced toxicity.
  • A case study of a 68-year-old man who developed delayed-onset lumbosacral polyradiculitis five months after undergoing proton beam therapy illustrates potential complications, with MRI and EMG confirming nerve root issues likely due to radiation.
  • The conclusion stresses the rarity of radiation-induced lumbosacral plexopathy and underscores the importance of ongoing patient follow-up and thorough review of cancer histories post-treatment.
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Background: The authors had previously developed AnaVu, a low-resource 3D visualization tool for stereoscopic/monoscopic projection of 3D models generated from pre-segmented MRI neuroimaging data. However, its utility in neuroanatomical education compared to conventional methods (specifically whether the stereoscopic or monoscopic mode is more effective) is still unclear.

Methods: A three-limb randomized controlled trial was designed.

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In this study 5-((2-((3-methoxy benzylidene)-amino)-phenyl)-diazenyl)-4,6-diphenyl pyrimidine-2(5H)-thione was synthesized. The pharmacological applications of pyrimidine analogs are restricted due to their poor pharmacokinetic properties. As a solution, a microbial exopolysaccharide (curdlan gum) was used to synthesize folic acid-conjugated pyrimidine-2(5H)-thione-encapsulated curdlan gum-PEGamine nanoparticles (FA-Py-CG-PEGamine NPs).

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Handwritten Text Recognition (HTR) is a challenging task due to the complex structures and variations present in handwritten text. In recent years, the application of gated mechanisms, such as Long Short-Term Memory (LSTM) networks, has brought significant advancements to HTR systems. This paper presents an overview of HTR using a gated mechanism and highlights its novelty and advantages.

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In this study, a novel multifunctional biofilm was fabricated using a straightforward casting process. The biofilm comprised gelatin, chitosan, 5-fluorouracil (5-FU)-conjugated zinc oxide nanoparticles, and polyvinyl alcohol plasticized with glycerol. The 5-FU-conjugated nanoparticles were synthesized via a single-step co-precipitation process, offering a unique approach.

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  • Green energy tech is critical for addressing environmental impacts of fossil fuels, with photoelectrochemical (PEC) cells being a promising method to produce hydrogen through water splitting.* -
  • The major challenge in advancing PEC technology to commercial use is developing effective photoelectrodes, leading to the construction of a heterostructure using MoS, TiO, and Au nanoparticles.* -
  • This new heterostructure significantly improves photocurrent density due to better charge transfer and light absorption, showcasing its potential to enhance PEC cell performance.*
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