Publications by authors named "Arzu Ruacan"
Leptin, a metabolic hormone, regulates the reproductive functions responding to both nutritional and body conditions. Embryonic stem cells play important roles in reproductive technology, but their derivation can be challenging. In this study, we evaluated the derivation rates of mouse embryonic stem cell (mESC) line from blastocysts developing in embryo culture media supplemented with different leptin concentrations.
View Article and Find Full Text PDFFibroblasts from a Familial Mediterranean Fever (FMF) patient were reprogrammed with episomal vectors by using the Neon Transfection System for the generation of integration-free induced pluripotent stem cells (iPSCs). The resulting iPSC line was characterized to determine the expression of pluripotency markers, proper differentiation into three germ layers, the presence of normal chromosomal structures as well as the lack of genomic integration. A homozygous missense mutation in the MEFV gene (p.
View Article and Find Full Text PDFBackground: We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation.
Methods: Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All samples were subject to histopathological evaluation, DNA quality control, and HPV-DNA detection.
Objective: The workload affects the quality of the pathology report. The aim of this study was to investigate the territorial distribution and productivity of pathology laboratories around Turkey and to estimate the staff workload.
Material And Method: A survey questioning the workload was sent to all Ministry of Health and university hospitals.
Article Synopsis
- The study assessed laryngeal preneoplastic lesions using classifications from the WHO, Ljubljana, and SINC by multiple observers, focusing on inter-observer agreement (IA).
- It involved evaluating H&E stained slides from 42 biopsies by 14 participants, with statistical analysis revealing significant differences in diagnoses among participants across the classifications.
- Although the mean correlation coefficients were higher for WHO compared to Ljubljana, the mean kappa values showed no significant differences, indicating that none of the classifications definitively provided better IA for these lesions.