Phosphorus-nitrogen compounds. Part 58. Syntheses, structural characterizations and biological activities of 4-fluorobenzyl-spiro(N/O)cyclotriphosphazene derivatives.

The starting compound, tetrachloro-4-fluorobenzyl-spiro(N/O)cyclotriphosphazene (), was synthesized from the substitution reaction of hexachlorocyclotriphosphazatriene (NPCl; trimer; ) with sodium 3-(4-fluorobenzylamino)-1-propanoxide (). Reactions of spiro () with excess 1-(2-aminoethyl)-piperidine, 4-(2-aminoethyl)-morpholine, 1-(2-hydroxyethyl)piperidine and 4-(2-aminoethyl)morpholine yielded the fully substituted cyclotriphosphazene derivatives (), respectively. Elemental analysis, mass spectrometry (ESI-MS), FTIR, H-, C- and P-NMR data confirmed the structure of the new cyclotriphosphazenes (); and the crystal structure of was also identified by X-ray crystallography.