Cervical Retrieval of Giant Posterior Mediastinal Parathyroid Adenoma with Bizarre Morphology.

Parathyroid adenoma is the most common cause of primary hyperparathyroidism and rarely reaches huge sizes. As the gland enlarges it may exhibit atypical morphology and extension to the mediastinum which may complicate the excision of the tumor while preserving the capsular integrity. We present a 35-year-old male patient who was referred to our department with a complaint of severe hypercalcemia.

Steroid Resistance/Dependence Might Be an Alarming Feature for Cytomegalovirus Infection Among Ulcerative Colitis Patients With Increased Disease Activity.

Background/Aims This study aimed to determine the prevalence of cytomegalovirus (CMV) infection among patients with moderate to severe active ulcerative colitis (UC) and to determine the risk factors for CMV infection according to the demographic features of these patients. Patients/Methods A total of 183 patients with severe or moderate active UC were enrolled in the study after retrospective analysis. The disease severity of UC was determined according to the Mayo Score.

Ancient Schwannoma as an exceptional thoracic spinal tumor: A case report.

Schwannomas are mostly benign tumors arising from the nerve sheath. These tumors can be found anywhere in the body. Depending on their locations, they may cause compressive symptoms as well as cosmetic or functional defects.

Coexistence of low-grade mucinous neoplasm and carcinoid (collision tumor) within multiple appendiceal diverticula: A case report.

Neoplasms of the appendix are very rare. They usually show glandular or neuroendocrine differentiation, and when they both occur in the same area, it is called a "collision tumor." Low-grade mucinous neoplasms associated with appendiceal diverticula are also uncommon.

Predicting pathological response and overall survival in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy: the role of PET/computed tomography.

Background: Gastric cancer is the second leading cause of cancer-related deaths, with a 5-year survival rate of about 20-25%. The ability to predict pathological response (PR) to neoadjuvant chemotherapy (NACT); hence, overall survival (OS) probability of patients can allow the clinician to individualize treatment strategies. We investigated the role of F-18 fluorodeoxyglucose PET-computed tomography (F-18 FDG PET/CT) in predicting histopathologic response and prognosis in locally advanced gastric cancer (LAGC) patients undergoing NACT.

Approach to primary thyroid lymphoma: case series.

Primary thyroid lymphomas are rare thyroid neoplasms. Mucosa Associated Lymphoid tissue (MALT) lymphoma and diffuse large B-cell Non-Hodgkin lymphoma are the most common types. It is more common in the elderly, and especially in women.

Coexistence of low-grade mucinous neoplasm and carcinoid (collision tumor) within multiple appendiceal diverticula: A case report.

Neoplasms of the appendix are very rare. They usually show glandular or neuroendocrine differentiation, and when they both occur in the same area, it is called a "collision tumor." Low-grade mucinous neoplasms associated with appendiceal diverticula are also uncommon.

Arteriography and Histopathology of Vascular Beds in Traumatically Amputated Fingers.

Background: The success of replantation following traumatic amputation is determined by the quality of the vascular anastomoses. The purpose of this study was to assess the vascularity of injured arteries from traumatically amputated digits using arteriographic and histopathological analysis.

Methods: 25 amputated digits were included in the study.

Giant pancreatic solid cystic desmoid tumor with two ectopic adrenal tissues.

A 19-year-old woman presented with painless swelling of the abdomen. During surgery, a giant mass measuring 37 cm×26 cm×12 cm within the distal pancreas invading the spleen was noted. The clinical diagnosis of a solid cystic pseudopapillary tumor of the pancreas was suspected.

DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease.

Background: Chronic hepatitis B infection is characterized by hepatic immune and inflammatory response with considerable variation in the rates of progression to cirrhosis. Genetic variants and environmental cues influence predisposition to the development of chronic liver disease; however, it remains unknown if aberrant DNA methylation is associated with fibrosis progression in chronic hepatitis B.

Results: To identify epigenetic marks associated with inflammatory and fibrotic processes of the hepatitis B-induced chronic liver disease, we carried out hepatic genome-wide methylation profiling using Illumina Infinium BeadArrays comparing mild and severe fibrotic disease in a discovery cohort of 29 patients.

Effects of mucosal TNF-alpha levels on treatment response in Crohn's disease patients receiving anti-TNF treatment.

Background/aims: We aimed to find out if mucosal TNF-α (m-TNF-α) levels have predictive impact on anti-TNF treatment response in Crohn's disease (CD).

Methodology: TNF-alpha values were determined with immunohistochemical staining of intestinal biopsies taken from 35 subjects on anti-TNF treatment for CD and 25 controls. Correlation between m-TNF-α levels and anti-TNF treatment were evaluated.

Significance of IMP3, nucleophosmin, and Ki-67 expression in papillary thyroid carcinoma.

The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference between papillary and micropapillary carcinomas with regard to clinicopathologic parameters beside IMP3, nucleophosmin, and Ki-67 proliferation index. It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions.

The effect of diclofenac on matrix metalloproteinase levels in the rotator cuff.

Introduction: Matrix metalloproteinases (MMPs) are involved in physiological events such as restructuring of the tissue, morphogenesis, wound healing and normal developmental process. Use of diclofenac sodium following rotator cuff repair can disrupt healing of tendon through acting on MMPs.

Materials And Methods: Supraspinatus tendons of rats (n = 84) were detached from their insertion on humerus, and repaired to anatomic footprint.

Gnathic osteosarcomas, experience of four institutions from Turkey.

Osteosarcoma is the most frequent primary gnathic sarcoma. Neither the etiology nor the variables effecting the prognosis are fully known due mostly to the rarity of gnathic osteosarcomas. To date a considerable number of clinicopathologic features have been suggested in the evaluation of gnathic osteosarcomas.

Histomorphological comparison of immobilization and denervation atrophies.

Objective: The aim of this study was to compare the histomorphological changes in the muscle tissue after immobilization and denervation atrophies in an animal model.

Methods: The study included 30 Ross-800 hybrid chickens (60 legs) divided into two study (immobilization and denervation) and two control groups. The knee and ankle joints were fixed with a Kirschner wire in the immobilization atrophy group and sciatic nerve resection was performed in the denervation group.

Lack of correlations among histopathological parameters, Ki-67 proliferation index and prognosis in pheochromocytoma patients.

Background: In this study prognostic correlations of histopathologic parameters and the Ki-67 proliferation index and as well as the diagnostic value of immunohistochemical markers in pheochromocytomas were evaluated.

Materials And Methods: A total of 22 patients diagnosed with a pheochromocytoma between 2000-2010 in Izmir Katip Celebi University Ataturk Training and Research Hospital were included. Diagnostic value of the PASS scoring system, and prognostic correlations of histopathologic parameters and Ki-67 proliferation index were investigated.

Oral epithelial barrier function and the role of nuclear factor kappa-β pathway in the pathogenesis of aphthous ulceration.

Background/aims: The normal oral mucosa is usually tolerant to its special microenvironment. Epithelial integrity and a wellmanaged immune system are important in sustaining harmony. A close look at the role played by adaptive immunity during recurrent aphthous ulcerations may throw some light into the pathogenesis.

The effects of hematological parameters and tumor-infiltrating lymphocytes on prognosis in patients with gastric cancer.

Background: It is well known that tumor-infiltrating lymphocytes (TIL) and, to a lesser extent, peripheral hematologic parameters from patients with cancer have to effect on prognosis. The aim of this study was to evaluate the effect of hematologic parameters and TIL on prognosis of patients with gastric cancer.

Methods: 236 patients who had diagnosed as gastric adenocarcinoma.

Nasopharyngeal nonkeratinizing (undifferentiated) monstrous cell carcinoma. A case report.

Background: The histologic type of nasopharyngeal carcinoma can be an important factor in the prognosis. The effects, if any, of the degree of cellular pleomorphism is uncertain.

Case: In this report, we present a case of nonkeratinizing, undifferentiated nasopharyngeal carcinoma with monstrous tumor giant cells.

Extensive fibrin accumulation and accompanying epithelial changes in the pathogenesis of ligneous mucosal disease (ligneous periodontitis).

Certain abnormal products of human tissues are resistant to degradation. The fibrillary ultrastructure of some of these are seen integrated with normal tissue components. The accumulations seen in colloid milium, lichen, and macular amyloidosis are of this type.

[Fungus ball in middle concha bullosa: a case report].

The enlargement of the middle concha as a pneumatized cavity is defined as concha bullosa. Concha bullosa is one of the most frequently encountered anatomic variations inside the nose. The histopathological changes caused by the infections that occur following the impairment of aeration of the conchal cavity filled with air are frequently found.

The cell with a thousand faces: detection of myoepithelial cells and their contributions in the cytological diagnosis of salivary gland tumors.

Myoepithelial cells are an important component of salivary gland tumors and are partly responsible from the diverse histology of them. In this study, we focus on the myoepithelial cell differentiation by using cytological morphology in a various types of salivary gland tumors especially with regard to their contribution to the diagnosis. The relation of myoepithelial cells with stromal matrix and the associated epithelial cells were evaluated.

Adrenocortical oncocytic neoplasm presenting with Cushing's syndrome: a case report.

Introduction: Oncocytic neoplasms occur in several organs and are most commonly found in the thyroid, kidneys and salivary glands. Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually non-functioning.

Case Presentation: We report the case of an adrenocortical oncocytic neoplasm with uncertain malignant potential in a 31-year-old man with Cushing's syndrome.

Multifocal skeletal tuberculosis involving the lumbar spine and a sacroiliac joint: MR imaging findings.

Sacroiliac joint tuberculosis is rare; its coexistence with vertebral tuberculosis is even rarer, with only a few such patients reported in the literature. We present magnetic resonance (MR) imaging findings of a patient with vertebral and sacroiliac joint tuberculosis, who had paravertebral, iliopsoas, and buttock abscesses accompanied by a gluteal pus-draining sinus tract. MR imaging is the most sensitive and specific imaging modality for diagnosing sacroiliitis at its early stage.