Publications by authors named "Aryani Pallerla"
Article Synopsis
- Only condoms effectively prevent both HIV and unplanned pregnancies, but user acceptability and partner cooperation can reduce their effectiveness.
- Researchers developed a novel injectable implant that combines antiretroviral drugs (like dolutegravir and cabotegravir) with hormonal contraceptives (etonogestrel and medroxyprogesterone acetate) for multipurpose prevention.
- Studies in mice showed that this implant is safe and well-tolerated, maintaining effective drug concentrations for 90 days after administration, indicating its potential as an effective preventive method.
Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable in-situ forming implant (ISFI) that is administered subcutaneously and can release the integrase inhibitor cabotegravir (CAB) above protective benchmarks for more than 6 months. CAB ISFIs are well-tolerated in female mice and female macaques showing no signs of toxicity or chronic inflammation.
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