Neem Leaf Glycoprotein in immunoregulation of cancer.

Cancer is a disease having global consequences. Though several new strategies and treatments have been developed so far, they often come with malicious side effects and this paved ways for demand of naturally extracted/driven product as potent anti-cancer agent owing to their reduced toxicity and side effects. One such common Indian household plant Neem (Azadirachta Indica) and its extract have variegated immunomodulatory effects as anti-cancer agent.

Involvement of Xeroderma Pigmentosum Complementation Group G (XPG) in epigenetic regulation of T-Helper (T) cell differentiation during breast cancer.

TNFα and IFN-γ secreted by CD4T-Helper (T) cells have antitumor activity followed by polarisation of T1 phenotype in response to IL-12 secreted by dendritic cells, inducing expression of XPG, Nucleotide-Excision Repair (NER) complex component, which is downregulated in breast cancer. Therefore, we investigated the involvement of XPG in T-cell differentiation in breast cancer. XPG knock-out (KO) PBMC and T1 polarised CD4 T-cells isolated from breast cancer and control subjects blood samples were used to observe mRNA expressions of associated genes, % enrichment of corresponding epigenetic markers, and m6A RNA methylation levels to study the molecular mechanisms involved.

Phase Transitions of Cu and Fe at Multiscales in an Additively Manufactured Cu-Fe Alloy under High-Pressure.

A state of the art, custom-built direct-metal deposition (DMD)-based additive manufacturing (AM) system at the University of Michigan was used to manufacture 50Cu-50Fe alloy with tailored properties for use in high strain/deformation environments. Subsequently, we performed preliminary high-pressure compression experiments to investigate the structural stability and deformation of this material. Our work shows that the alpha (BCC) phase of Fe is stable up to ~16 GPa before reversibly transforming to HCP, which is at least a few GPa higher than pure bulk Fe material.

Disjoining pressure and capillarity in the constrained vapor bubble heat transfer system.

Using the disjoining pressure concept in a seminal paper, Derjaguin, Nerpin and Churaev demonstrated that isothermal liquid flow in a very thin film on the walls of a capillary tube enhances the rate of evaporation of moisture by several times. The objective of this review is to present the evolution of the use of Churaev's seminal research in the development of the Constrained Vapor Bubble (CVB) heat transfer system. In this non-isothermal "wickless heat pipe", liquid and vapor flow results from gradients in the intermolecular force field, which depend on the disjoining pressure, capillarity and temperature.